DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sug and zic3

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001005691.1	Gene:	zic3 / 448197	XenbaseID:	XB-GENE-480431	Length:	441	Species:	Xenopus tropicalis

Alignment Length:	377	Identity:	119/377 - (31%)
Similarity:	160/377 - (42%)	Gaps:	97/377 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QKSIFNS-GPHSRGIYEPPLGYFTP-----------------------------YNTP-PYIAAY 38
            |..:|.| ||  .||.|||.....|                             :..| ||.|..
Frog   115 QHGLFASHGP--PGIGEPPGHLIFPGLHEQSSSHTSSNGHVVNGQMHLGLRGDIFGRPDPYRAVP 177

  Fly    39 SDSGSWLADHHQHHQQQHQQHQQQMQHIRFPTPPITPPRPIAGYGYRQRTQSVIMKARGQQDELC 103
            |..    .||:...|..:..|.....::.....|        |..:|...|.:      :|:..|
Frog   178 SPR----TDHYAAAQFHNYNHMNMSMNVAAHHGP--------GAFFRYMRQPI------KQELSC 224

  Fly   104 R----SPVEFPDDSKSCSSSSECGTASDFVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYY 164
            :    ||:..|..:                     |||.|.::..|..|:|..| :.......:.
Frog   225 KWLEESPMNRPQKT---------------------CDRTFSSMHELVTHMTMEH-VGGPEQTNHI 267

  Fly   165 CRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCS 227
            |.|..|.|..:.|.|:||::.|.|.||.|||..|..  |.|.|:|:||||||.|:|:||||:||.
Frog   268 CYWEECPRGGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCE 332

  Fly   228 FEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFKHSIHLIASQPLTL 292
            ||||.:.::|||||.||...|:.:|||:|||  |.|.||.|||||||:|.  |......|.|
Frog   333 FEGCDRRFANSSDRKKHMHVHTSDKPYICKV--CDKSYTHPSSLRKHMKV--HESQGSDSSP--- 390

  Fly   293 PSVPCLLEASS--ESAFTCLPAASSVESTSSSSSARYYDDSNNEPSDYSLKP 342
                   .|||  |||......:::.|..|.:|||.:  .:||...:..|.|
Frog   391 -------AASSGYESATPPAMVSANSEEPSKNSSATH--QTNNSSHNTGLLP 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	8/19 (42%)
		zf-H2C2_2	183..207	CDD:290200	11/25 (44%)
		COG5048	192..>271	CDD:227381	46/80 (58%)
		C2H2 Zn finger	198..218	CDD:275368	12/21 (57%)
		zf-H2C2_2	210..237	CDD:290200	17/26 (65%)
		C2H2 Zn finger	226..248	CDD:275368	12/21 (57%)
		C2H2 Zn finger	256..277	CDD:275368	14/20 (70%)
zic3	NP_001005691.1	zf_ZIC	216..261	CDD:375792	14/72 (19%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		SFP1	<295..379	CDD:227516	51/85 (60%)
		C2H2 Zn finger	301..323	CDD:275368	12/21 (57%)
		C2H2 Zn finger	331..353	CDD:275368	12/21 (57%)
		C2H2 Zn finger	361..381	CDD:275368	15/23 (65%)
		CiPC	<365..>433	CDD:374124	28/81 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..441		22/73 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910