DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sug and Zic2

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_033600.3	Gene:	Zic2 / 22772	MGIID:	106679	Length:	529	Species:	Mus musculus

Alignment Length:	342	Identity:	104/342 - (30%)
Similarity:	153/342 - (44%)	Gaps:	84/342 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IFNSGPHSRGIYEPPLGYFTPYNTPPYIAAY-------------SDSGSWLADHHQHHQQQHQQH 59
            :|......|.:..|        .|.||.||.             .:..:..|.||.||.
Mouse   187 VFGRSEQYRQVASP--------RTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHH------ 237

  Fly    60 QQQMQHIRFPTPPITPPRPIAGYGYRQRTQSVIMKARGQQDELCR--SPVEFPDDSKSCSSSSEC 122
                             .|.|.:.| .|.|.:      :|:.:|:  .|.:..:..||
Mouse   238 -----------------HPGAFFRY-MRQQCI------KQELICKWIDPEQLSNPKKS------- 271

  Fly   123 GTASDFVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHT 187
                        |::.|.|:..|..||:..| :.......:.|.|..|.|..:.|.|:||::.|.
Mouse   272 ------------CNKTFSTMHELVTHVSVEH-VGGPEQSNHVCFWEECPREGKPFKAKYKLVNHI 323

  Fly   188 RTHTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSM 250
            |.||.|||..|..  |.|.|:|:||||||.|:|:||||::|.||||.:.::|||||.||...|:.
Mouse   324 RVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTS 388

  Fly   251 EKPYMCKVAGCQKRYTDPSSLRKHVKTFKHSIHLIASQPLT-----LPSVPCLLEASSE--SAFT 308
            :|||:||:  |.|.||.|||||||:|..:.|.....|.|..     ..:.|.|:..|:|  |:..
Mouse   389 DKPYLCKM--CDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSN 451

  Fly   309 CLPAASSVESTSSSSSA 325
            ..|||::..:.:::::|
Mouse   452 LSPAAAAAAAAAAAAAA 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	8/19 (42%)
		zf-H2C2_2	183..207	CDD:290200	11/25 (44%)
		COG5048	192..>271	CDD:227381	44/80 (55%)
		C2H2 Zn finger	198..218	CDD:275368	12/21 (57%)
		zf-H2C2_2	210..237	CDD:290200	16/26 (62%)
		C2H2 Zn finger	226..248	CDD:275368	12/21 (57%)
		C2H2 Zn finger	256..277	CDD:275368	13/20 (65%)
Zic2	NP_033600.3	zf_ZIC	249..294	CDD:408166	13/70 (19%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		SFP1	<328..412	CDD:227516	49/85 (58%)
		C2H2 Zn finger	334..356	CDD:275368	12/21 (57%)
		C2H2 Zn finger	364..386	CDD:275368	12/21 (57%)
		C2H2 Zn finger	394..414	CDD:275368	14/21 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..451		15/45 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910