Protein Alignment sug and GLIS3

DIOPT Version :10

• Sequence 1: NP_610826.1
• Gene: sug / 36424
• FlyBaseID: FBgn0033782
• Length: 384
• Species: Drosophila melanogaster
• Sequence 2: NP_001035878.1
• Gene: GLIS3 / 169792
• HGNCID: 28510
• Length: 930
• Species: Homo sapiens
• Alignment Length: 429
• Identity: 134/429 - (31%)
• Similarity: 176/429 - (41%)
• Gaps: 121/429 - (28%)

  Fly    16 RGIYEPPLGYFTPYNTPPYIAAYSDSGSWLADHHQHHQQQHQQH---------QQQMQH------ 65
            :|:...|.|...|        ||.:.|:.     :|.:.|..:|         ...:||
Human   370 KGVLVAPGGLALP--------AYGEDGAL-----EHERMQQLEHGGLQPGLVNHMVVQHGLPGPD 421

  Fly    66 ------------IRFP---------------TPPITPPRPIAGYGYRQRTQSVIMKARGQQDELC 103
                        ..||               .||..||.|...:.:....:   :....||..|.
Human   422 SQSAGLFKTERLEEFPGSTVDLPPAPPLPPLPPPPGPPPPYHAHAHLHHPE---LGPHAQQLALP 483

  Fly   104 RSPVEFPDDSKSCSSSSECGTASDFVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWR 168
            ::.::  ||.:.      .|......|.|.||..::|..:.|.:|:.:.| |.......:.|.|.
Human   484 QATLD--DDGEM------DGIGGKHCCRWIDCSALYDQQEELVRHIEKVH-IDQRKGEDFTCFWA 539

  Fly   169 GCQRSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGC 231
            ||.|..:.||||||:|:|.|.|:.|||::|..  |||:|||.||||||:|||:|||||.|...||
Human   540 GCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGC 604

  Fly   232 QKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFKHS--------------- 281
            |||:||||||.||.|||...|||.|::.||.||||||||||||||.  ||
Human   605 QKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKA--HSSKEQQARKKLRSSTE 667

  Fly   282 IH---------LIASQPLTLP--------------------SVPCLLEASSESAFTCLPAASSVE 317
            :|         :.:.||.|.|                    |.|......|..:.|...|.....
Human   668 LHPDLLTDCLTVQSLQPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPH 732

  Fly   318 STSSSSSARYYDDSNNEPSDYSLKP--KQDA---EFSPS 351
            ..|..|.......|.:.||. .|.|  ..||   .|:||
Human   733 PVSHPSPGHNVQGSPHNPSS-QLPPLTAVDAGAERFAPS 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	11/19 (58%)
		COG5048	192..>271	CDD:227381	54/80 (68%)
		C2H2 Zn finger	198..218	CDD:275368	14/21 (67%)
		C2H2 Zn finger	226..248	CDD:275368	15/21 (71%)
		C2H2 Zn finger	256..277	CDD:275368	16/20 (80%)
GLIS3	NP_001035878.1	SFP1	<558..652	CDD:227516	63/95 (66%)
		C2H2 Zn finger	569..591	CDD:275368	14/21 (67%)
		C2H2 Zn finger	599..621	CDD:275368	15/21 (71%)
		C2H2 Zn finger	629..651	CDD:275368	17/23 (74%)