DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sug and GLIS1

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001377765.1	Gene:	GLIS1 / 148979	HGNCID:	29525	Length:	803	Species:	Homo sapiens

Alignment Length:	237	Identity:	99/237 - (41%)
Similarity:	124/237 - (52%)	Gaps:	55/237 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 HQQQMQHIRFPTP-PIT--PPRP-IAGYGYRQRTQSVIMKARGQQDELCRSPVEFPDDSKSCSSS 119
            |||.:     |.| |::  ||.| :.|.|.....:.|    .|:|
Human   335 HQQGL-----PPPYPLSQLPPGPSLGGLGLGLAGRVV----AGRQ-------------------- 370

  Fly   120 SECGTASDFVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKML 184
                     .|.|.||...::..:.|.:|:.:.| |.......:.|.|.||.|..:.||||||:|
Human   371 ---------ACRWVDCCAAYEQQEELVRHIEKSH-IDQRKGEDFTCFWAGCVRRYKPFNARYKLL 425

  Fly   185 VHTRTHTKEKPHRC----------HLCEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSS 239
            :|.|.|:.|||::|          ..|.|:|||.||||||:|||:|||||.|...|||||:||||
Human   426 IHMRVHSGEKPNKCMPFPQFFHEFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSS 490

  Fly   240 DRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFKHS 281
            ||.||.|||...|||.|::.||.||||||||||||||.  ||
Human   491 DRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKA--HS 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	11/19 (58%)
		zf-H2C2_2	183..207	CDD:290200	11/33 (33%)
		COG5048	192..>271	CDD:227381	53/88 (60%)
		C2H2 Zn finger	198..218	CDD:275368	13/29 (45%)
		zf-H2C2_2	210..237	CDD:290200	19/26 (73%)
		C2H2 Zn finger	226..248	CDD:275368	15/21 (71%)
		C2H2 Zn finger	256..277	CDD:275368	16/20 (80%)
GLIS1	NP_001377765.1	C2H2 Zn finger	376..395	CDD:275368	4/18 (22%)
		C2H2 Zn finger	406..431	CDD:275368	14/24 (58%)
		COG5048	447..>522	CDD:227381	49/74 (66%)
		C2H2 Zn finger	450..469	CDD:275368	12/18 (67%)
		C2H2 Zn finger	477..499	CDD:275368	15/21 (71%)
		C2H2 Zn finger	507..529	CDD:275368	17/23 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910