DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AspRS and DPS1

DIOPT Version :9

Sequence 1:	NP_001260930.1	Gene:	AspRS / 36420	FlyBaseID:	FBgn0002069	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_013083.1	Gene:	DPS1 / 850643	SGDID:	S000003941	Length:	557	Species:	Saccharomyces cerevisiae

Alignment Length:	552	Identity:	293/552 - (53%)
Similarity:	367/552 - (66%)	Gaps:	27/552 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VEDKEQVA------NGEQVSKKGAKKLAKAAKKAEQKAENASTAAANNAGGD---SAEDHAAGRY 57
            ||:..:.|      :|:.:|||..|||.|..:|..:|.|.|....|.....:   :|||.|...|
Yeast    11 VEESAEPAQVILGEDGKPLSKKALKKLQKEQEKQRKKEERALQLEAEREAREKKAAAEDTAKDNY 75

  Fly    58 GLSEMIQSKDKRSER------NFVPVSELSGQVGKGLVWVRGRVHTSRAKGKQ-CFLILRQQSST 115
            |...:|||:|  |:|      .||.:.|......:  |..|.|||.:|.:|.. .||.||||:|.
Yeast    76 GKLPLIQSRD--SDRTGQKRVKFVDLDEAKDSDKE--VLFRARVHNTRQQGATLAFLTLRQQASL 136

  Fly   116 VQCILAVG--DVISKQMVKFAGNIPKESIIDIQAKPVAVSSKIESCTEQSLELSVEQIFVISQAK 178
            :|.::...  ..|||.|||:||::..|||:.::.....|...|:|.|.|:||:.:.:|:.||:..
Yeast   137 IQGLVKANKEGTISKNMVKWAGSLNLESIVLVRGIVKKVDEPIKSATVQNLEIHITKIYTISETP 201

  Fly   179 AQLPLQIEDASRPENADDAEGLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEQ 243
            ..||:.:|||||.|...:|.||.: ||.|||||.||:||||..||||||::||||.|||:.|..:
Yeast   202 EALPILLEDASRSEAEAEAAGLPV-VNLDTRLDYRVIDLRTVTNQAIFRIQAGVCELFREYLATK 265

  Fly   244 GFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSN 308
            .|||:||||::.|.||||::||.|:|||..||||||||..||..|.|||::||.:|.|||||:||
Yeast   266 KFTEVHTPKLLGAPSEGGSSVFEVTYFKGKAYLAQSPQFNKQQLIVADFERVYEIGPVFRAENSN 330

  Fly   309 THRHLTEFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGLRDKYAKEIESVGQQYKVDAFKFLEPP 373
            ||||:|||.|||:||||:.||||||.|:...|..||..|..::|.|||.|.:||.|:.||..:..
Yeast   331 THRHMTEFTGLDMEMAFEEHYHEVLDTLSELFVFIFSELPKRFAHEIELVRKQYPVEEFKLPKDG 395

  Fly   374 LI--LQFADGVAMLREAGVETGDEEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLAIRPFYTMPD 436
            .:  |.:.:|:.|||.||.|.||.|||||.|||.||:||:.||||||||||||||.|||||||||
Yeast   396 KMVRLTYKEGIEMLRAAGKEIGDFEDLSTENEKFLGKLVRDKYDTDFYILDKFPLEIRPFYTMPD 460

  Fly   437 PNNPVYSNSYDMFMRGEEILSGAQRIHDPEYLIERAKHHGI--DTSKIAAYIESFRYGCPPHAGG 499
            |.||.||||||.||||||||||||||||...|.||.|.||:  :...:..|.:.|.|||||||||
Yeast   461 PANPKYSNSYDFFMRGEEILSGAQRIHDHALLQERMKAHGLSPEDPGLKDYCDGFSYGCPPHAGG 525

  Fly   500 GIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 531
            |||:|||||.||.|.|||:.|:||||||||.|
Yeast   526 GIGLERVVMFYLDLKNIRRASLFPRDPKRLRP 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS	NP_001260930.1	PLN02850	49..531	CDD:215456	276/494 (56%)
		AspRS_cyto_N	89..187	CDD:239815	38/100 (38%)
		AsxRS_core	203..527	CDD:238399	210/327 (64%)
DPS1	NP_013083.1	PLN02850	19..557	CDD:215456	289/542 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346812
Domainoid	1	1.000	417	1.000	Domainoid score	I77
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1032
Inparanoid	1	1.050	525	1.000	Inparanoid score	I189
Isobase	1	0.950	-	0	Normalized mean entropy	S293
OMA	1	1.010	-	-		QHG60941
OrthoFinder	1	1.000	-	-		FOG0004194
OrthoInspector	1	1.000	-	-		oto99546
orthoMCL	1	0.900	-	-		OOG6_100778
Panther	1	1.100	-	-	LDO	PTHR43450
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1432
SonicParanoid	1	1.000	-	-		X2940
TreeFam	1	0.960	-	-
	16	15.740