Protein Alignment AspRS and NARS1

DIOPT Version :10

• Sequence 1: NP_476609.1
• Gene: AspRS / 36420
• FlyBaseID: FBgn0002069
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_004530.1
• Gene: NARS1 / 4677
• HGNCID: 7643
• Length: 548
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 144/560 - (25%)
• Similarity: 239/560 - (42%)
• Gaps: 87/560 - (15%)

  Fly     2 VEDKEQVANGEQVSKKGAKKLAKAAKKAEQKAENASTAAANNAGGDSAEDHAAGRYGLSE----M 62
            |:.:::......:||...|.:.|...:.:.|:|:...        ..|||.......|.|    .
Human    46 VDSQKENERWNVISKSQLKNIKKMWHREQMKSESREK--------KEAEDSLRREKNLEEAKKIT 102

  Fly    63 IQSKDKRSERNFVPVSELSGQVGKGLVWVRGRVHTSRAKGKQ-CFLILRQQSSTVQCILA----- 121
            |::.....|...|.:..|.|..|: .|.|.|.||..|.:||. .||:||..:..:||:||
Human   103 IKNDPSLPEPKCVKIGALEGYRGQ-RVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQ 166

  Fly   122 --VGDVISKQMVKFAGNIPKESIIDIQAKPVAVSSKIESCTEQSLELSVEQIFVISQAKAQLPLQ 184
              .|.::|.:     .::....::::..|......        ..|||.:...:|..|.|
Human   167 CYNGVLLSTE-----SSVAVYGMLNLTPKGKQAPG--------GHELSCDFWELIGLAPA----- 213

  Fly   185 IEDASRPENADDAEGLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEQGFTEIH 249
                   ..||:.  :|...:.|.:|:||.:.:|......|.:..:.|.|.|||...::|:.|:.
Human   214 -------GGADNL--INEESDVDVQLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYYEVT 269

  Fly   250 TPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLT 314
            .|.::....||||.:|.:.||.:.|:|.||.|||.:..:.|..| |:.:...:|||.|.|.|||.
Human   270 PPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGD-VFCIAQSYRAEQSRTRRHLA 333

  Fly   315 EFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGLRDKYAKEIESVGQQYKVDAFKFL-------EP 372
            |:..::.|..|.            ||..:...|.|.....::.:   .|..|...:       :|
Human   334 EYTHVEAECPFL------------TFDDLLNRLEDLVCDVVDRI---LKSPAGSIVHELNPNFQP 383

  Fly   373 P----LILQFADGVAMLREAGVETGD------EEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLA 427
            |    ..:.::|.:..|:|..|:..|      .||:....|:|:...:     .:..:|.:||:.
Human   384 PKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIPEAPERLMTDTI-----NEPILLCRFPVE 443

  Fly   428 IRPFYTMPDPNNPVYSNSYDMFMRG-EEILSGAQRIHDPEYLIERAKHHGIDTSKIAAYIESFRY 491
            |:.||....|.:...:.|.|:.|.. .||:.|:.||.|.|.::...|..|||.:....|.:..:|
Human   444 IKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKY 508

  Fly   492 GCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 531
            |..||.|.|:|:||.:...|...:||...::||..:|.||
Human   509 GTCPHGGYGLGLERFLTWILNRYHIRDVCLYPRFVQRCTP 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AspRS	NP_476609.1	PLN02850	49..531	CDD:215456	135/511 (26%)
NARS1	NP_004530.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..91		5/29 (17%)
		AsnRS_cyto_like_N	127..209	CDD:239818	22/94 (23%)
		AsxRS_core	225..544	CDD:238399	95/339 (28%)