DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AspRS and dars1

DIOPT Version :9

Sequence 1:	NP_001260930.1	Gene:	AspRS / 36420	FlyBaseID:	FBgn0002069	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001071079.1	Gene:	dars1 / 324025	ZFINID:	ZDB-GENE-061110-135	Length:	531	Species:	Danio rerio

Alignment Length:	528	Identity:	361/528 - (68%)
Similarity:	421/528 - (79%)	Gaps:	7/528 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKEQVANGEQVSKKGAKKLAKAAKKAEQKAENASTAAANNAGGDSAEDHAAGRYGLSEMIQSKDK 68
            ::||.|..::..||..|:..|||||||::|:.||.....     ..:|.|..|||:..|:||:.|
Zfish    11 EEEQQAQSKKALKKQQKEAEKAAKKAEKQAKLASEQQET-----EEDDFAKDRYGICPMVQSQQK 70

  Fly    69 RSERNFVPVSELSGQVGKGLVWVRGRVHTSRAKGKQCFLILRQQSSTVQCILAVGDVISKQMVKF 133
             .:|..|.|.:|:.:..:..:|||.|:||||||||||||:||.|..|||.:|||||..|||||||
Zfish    71 -LDRALVRVQDLTLEKAEQQIWVRARIHTSRAKGKQCFLVLRHQQFTVQALLAVGDRASKQMVKF 134

  Fly   134 AGNIPKESIIDIQAKPVAVSSKIESCTEQSLELSVEQIFVISQAKAQLPLQIEDASRPENADDAE 198
            |.||.||||||::|....|..|||||::|.:||.||:||||||::|:||||:|||.|||...|.|
Zfish   135 AANITKESIIDVEAVVKKVEQKIESCSQQDVELHVERIFVISQSEARLPLQLEDAVRPEGEGDEE 199

  Fly   199 GLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEQGFTEIHTPKIISAASEGGAN 263
            | ...|||||||||||:||||..:||||||::|||:||||.|..:||.||.||||||||||||||
Zfish   200 G-RATVNQDTRLDNRVIDLRTTTSQAIFRLQSGVCQLFRDTLINKGFVEIQTPKIISAASEGGAN 263

  Fly   264 VFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYH 328
            ||||||||.||||||||||||||.|.||||||:.||.||||||||||||||||||||:||||.||
Zfish   264 VFTVSYFKTSAYLAQSPQLYKQMCICADFDKVFCVGPVFRAEDSNTHRHLTEFVGLDIEMAFSYH 328

  Fly   329 YHEVLHTIGNTFTSIFKGLRDKYAKEIESVGQQYKVDAFKFLEPPLILQFADGVAMLREAGVETG 393
            ||||:.:|.:|...|||||||::..||::|.:||..:.||||||.|.|::.:|:||||.||||.|
Zfish   329 YHEVIDSITDTMVQIFKGLRDRFQTEIQTVNKQYPSEPFKFLEPTLRLEYKEGLAMLRAAGVEMG 393

  Fly   394 DEEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLAIRPFYTMPDPNNPVYSNSYDMFMRGEEILSG 458
            ||||||||||||||||||.|||||||:|||:|||:||||||||||||.|||||||||||||||||
Zfish   394 DEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPNNPKYSNSYDMFMRGEEILSG 458

  Fly   459 AQRIHDPEYLIERAKHHGIDTSKIAAYIESFRYGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFP 523
            ||||||.:.|.|||.||.||..||.|||:|||||.|||||||||:|||.||||||.|:|:|||||
Zfish   459 AQRIHDAQLLTERAMHHNIDLEKIKAYIDSFRYGAPPHAGGGIGLERVTMLYLGLHNVRQTSMFP 523

  Fly   524 RDPKRLTP 531
            ||||||||
Zfish   524 RDPKRLTP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS	NP_001260930.1	PLN02850	49..531	CDD:215456	343/481 (71%)
		AspRS_cyto_N	89..187	CDD:239815	66/97 (68%)
		AsxRS_core	203..527	CDD:238399	251/323 (78%)
dars1	NP_001071079.1	PLN02850	11..531	CDD:215456	359/526 (68%)
		AspRS_cyto_N	90..188	CDD:239815	66/97 (68%)
		AsxRS_core	204..527	CDD:238399	251/322 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596862
Domainoid	1	1.000	510	1.000	Domainoid score	I313
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1032
Inparanoid	1	1.050	707	1.000	Inparanoid score	I640
OMA	1	1.010	-	-		QHG60941
OrthoDB	1	1.010	-	-		D267439at33208
OrthoFinder	1	1.000	-	-		FOG0004194
OrthoInspector	1	1.000	-	-		oto40948
orthoMCL	1	0.900	-	-		OOG6_100778
Panther	1	1.100	-	-	LDO	PTHR43450
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1432
SonicParanoid	1	1.000	-	-		X2940
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800