DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AspRS and LysRS

DIOPT Version :9

Sequence 1:	NP_001260930.1	Gene:	AspRS / 36420	FlyBaseID:	FBgn0002069	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	139/587 - (23%)
Similarity:	229/587 - (39%)	Gaps:	119/587 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SKKGAKKLAKAAKKAEQKAENASTAAANNAGG----DSAEDHAAG---RYGLSEMIQSKDKRSE- 71
            :|...|:..||.:||::|||.|:.|.|.|..|    .:||:....   .:.|......:.|||.
  Fly    42 TKLELKRRLKAEQKAKEKAEKAAAAPAENTAGKKKSSAAEEEEISPNEYFKLRSAAVQELKRSPA 106

  Fly    72 --------------RNFVPVSELSGQVGKGL----VWVRGRVHTSRAKG-KQCFLILRQQSSTVQ 117
                          .:|:...|.|.:.|:.|    :.|.||||..|..| |..|..||.:...||
  Fly   107 TDPYPHKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKVQ 171

  Fly   118 CILAVGDVISKQMVKF-AGNIPKESIIDIQAKPVAVSSKIESCTEQSLELSV--EQIFVISQAKA 179
            .:.:.....|:...:. ...:.:..||.:...|        ..|::. ||||  .:|.::|....
  Fly   172 VMASAKSYKSEADFEIDTSKLRRGDIIGVVGHP--------GKTKKG-ELSVMPSEIKLLSPCLH 227

  Fly   180 QLP-LQIEDASRPENADDAEGLNIRVNQDTRLDNRVLDLRTPAN-QAIFRLEAGVCRLFRDILTE 242
            .|| |..             ||.   :::||...|.|||....| :..|::.|.:....|..|..
  Fly   228 MLPHLHF-------------GLK---DKETRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDR 276

  Fly   243 QGFTEIHTPKIISAASEGGANVFTVSY--FKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAE 305
            .||.||.||.:...|....|..|...:  .|...::..:|:||.:|.:....|:||.:|..||.|
  Fly   277 LGFLEIETPMMNMIAGGATAKPFVTHHNDLKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNE 341

  Fly   306 DSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGLRDKY------------AKEIESV 358
            ..:. .|..||...:..||:. .|.:::.......:.:.|.:|..|            .:|::..
  Fly   342 GIDL-THNPEFTTCEFYMAYA-DYADIMDITEQLVSGMVKAIRGSYKVIYHPEGPEGPEQELDFT 404

  Fly   359 GQQYKVDAFKFLEPPLILQFADGVAMLREAGVETGDEEDLSTPNEKLLGRLVKAKYD-------T 416
            ....:|...|.||..|.::|         ...:|.:    |....:.|.:|. ||:.       |
  Fly   405 PPFKRVSMIKTLEEKLQVKF---------PAADTFN----SPETNQFLSQLC-AKHQVECPAPRT 455

  Fly   417 DFYILDKF------PLAIRPFYTMPDP-----------NNPVYSNSYDMFMRGEEILSGAQRIHD 464
            ...:|||.      ...:.|.:....|           :.|..:..:::|:..:||.:....::|
  Fly   456 TARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKYHRSIPGLTERFELFVAKKEICNAYTELND 520

  Fly   465 PEYLIER------AKHHGIDTSKIA--AYIESFRYGCPPHAGGGIGMERVVMLYLGLDNIRKTSM 521
            |....||      .|..|.|.:::.  .:..|..||.||..|.|:|::|:.|.....:||::..:
  Fly   521 PVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPPTGGFGMGIDRLAMFLTDSNNIKEVLL 585

  Fly   522 FP 523
            ||
  Fly   586 FP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS	NP_001260930.1	PLN02850	49..531	CDD:215456	125/549 (23%)
		AspRS_cyto_N	89..187	CDD:239815	27/102 (26%)
		AsxRS_core	203..527	CDD:238399	85/368 (23%)
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	139/587 (24%)
		LysRS_N	141..250	CDD:239817	33/133 (25%)
		LysRS_core	253..591	CDD:238398	79/351 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473204
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840