DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AspRS and Nars1

DIOPT Version :9

Sequence 1:	NP_001260930.1	Gene:	AspRS / 36420	FlyBaseID:	FBgn0002069	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_006254906.1	Gene:	Nars1 / 291556	RGDID:	1307238	Length:	559	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	147/562 - (26%)
Similarity:	244/562 - (43%)	Gaps:	91/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VEDKEQVANGEQVSKKGAKKLAKAAKKAEQKAENASTAAANNAGGDSAEDHAAGRYGLSE----M 62
            |:.:::....:.:||...|.:.|...:.:.|:::...        ..|||:......|.|    :
  Rat    57 VDSQKENERWDVISKSQMKNIKKMWHREQMKSDSREK--------KEAEDNLRREKNLEEAKKII 113

  Fly    63 IQSKDKRSERNFVPVSELSGQVGKGLVWVRGRVHTSRAKGKQ-CFLILRQQSSTVQCILA----- 121
            |::.....|...|.:|.|.|..|: .|.|.|.||..|.:||. .||:||..:..:||:|:
  Rat   114 IKNDPSLPEPACVKISALEGYRGQ-RVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLSDDLCQ 177

  Fly   122 --VGDVISKQMVKFAGNIPKESIIDIQAKPVAVSSKIESCTEQSL-----ELSVEQIFVISQAKA 179
              .|.|:|.:                  ..|||...:....:...     |||.:...::..|.|
  Rat   178 CYNGVVLSTE------------------SSVAVYGTLNLTPKGKQAPGGHELSCDFWELVGLAPA 224

  Fly   180 QLPLQIEDASRPENADDAEGLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEQG 244
                        ..||:.  :|...:.|.:|:||.:.:|......|.:..:.:.|.|||...::|
  Rat   225 ------------GGADNL--INEESDVDVQLNNRHMMIRGENMSKILKARSMITRCFRDHFFDRG 275

  Fly   245 FTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNT 309
            :.|:.||.::....||||.:|.:.||.:.|:|.||.|||.:..:.|..| |:.:...:|||.|.|
  Rat   276 YCEVTTPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGD-VFCIAQSYRAEQSRT 339

  Fly   310 HRHLTEFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGLRDKYAKEIESVGQQ------YKVDA-F 367
            .|||.||..::.|..|.            ||..:...|.|.....::.|.:.      |.::. |
  Rat   340 RRHLAEFTHVEAECPFL------------TFEDLLSRLEDLVCDVVDRVLKSPVASIVYDLNPNF 392

  Fly   368 KFLEPPL-ILQFADGVAMLREAGVETGD------EEDLSTPNEKLLGRLVKAKYDTDFYILDKFP 425
            |..:.|. .:.::|.:..|||..|:..|      .:|:....|:|:...:     .:..:|.:||
  Rat   393 KAPKRPFRRMNYSDAIEWLREHDVKKEDGTFYEFGDDIPEAPERLMTDTI-----NEPILLCRFP 452

  Fly   426 LAIRPFYTMPDPNNPVYSNSYDMFMRG-EEILSGAQRIHDPEYLIERAKHHGIDTSKIAAYIESF 489
            :.|:.||....|.:|..:.|.|:.|.. .||:.|:.|..|.|.::|..|..|||.:....|.:..
  Rat   453 VEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRSWDSEEILEGYKREGIDPAPYYWYTDQR 517

  Fly   490 RYGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 531
            :||..||.|.|:|:||.:...|...:||...::||..:|..|
  Rat   518 KYGTCPHGGYGLGLERFLSWILNRYHIRDVCLYPRFLQRCRP 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS	NP_001260930.1	PLN02850	49..531	CDD:215456	140/513 (27%)
		AspRS_cyto_N	89..187	CDD:239815	26/110 (24%)
		AsxRS_core	203..527	CDD:238399	98/338 (29%)
Nars1	XP_006254906.1	AsnS	136..559	CDD:223096	129/473 (27%)
		AsnRS_cyto_like_N	138..220	CDD:239818	24/99 (24%)
		AsxRS_core	236..555	CDD:238399	98/336 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810