DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AspRS and dars-1

DIOPT Version :9

Sequence 1:	NP_001260930.1	Gene:	AspRS / 36420	FlyBaseID:	FBgn0002069	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_499089.1	Gene:	dars-1 / 176334	WormBaseID:	WBGene00001094	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	326/533 - (61%)
Similarity:	398/533 - (74%)	Gaps:	16/533 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ANGEQ--VSKKGAKKLAKAAKKAE---QKAENASTAAANNAGGDSAEDHAAGRYGLSEMIQSKDK 68
            |.|||  :|||...|||:.|||.|   :|..|...|||.:     .||.:...||...::.||:|
Worm     5 AEGEQPKLSKKELNKLARKAKKDEKAGEKGGNQQQAAAMD-----QEDASKDFYGSYGLVNSKEK 64

  Fly    69 RSERNFVPVSELSGQVGKGLVWVRGRVHTSRAKGKQCFLILRQQSSTVQCILAVGDVISKQMVKF 133
            : ..||:.|.|::.......||||||:||:|:|||.|||:|||...|||..:.:.:.|||||:||
Worm    65 K-VLNFLKVKEINVSNATKDVWVRGRIHTTRSKGKNCFLVLRQGVYTVQVAMFMNEKISKQMLKF 128

  Fly   134 AGNIPKESIIDIQAKPVAVSSKIESCTEQSLELSVEQIFVISQAKAQLPLQIEDASR-----PEN 193
            ..:|.||||:|:.|....|.:.|||||::.:||..:|:||:|.:..:||||||||||     .|.
Worm   129 VSSISKESIVDVYATINKVDNPIESCTQKDVELLAQQVFVVSTSAPKLPLQIEDASRRAPTDEEK 193

  Fly   194 ADDAEGLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEQGFTEIHTPKIISAAS 258
            |.:.|.....||.||||||||:|||||.:.||||::||:|..||:||..:||.||..||||||.|
Worm   194 ASEQENQLAVVNLDTRLDNRVIDLRTPTSHAIFRIQAGICNQFRNILDVRGFVEIMAPKIISAPS 258

  Fly   259 EGGANVFTVSYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEM 323
            |||||||.|||||.|||||||||||||||||.||:||||:|.||||||||||||:||||||||||
Worm   259 EGGANVFEVSYFKGSAYLAQSPQLYKQMAIAGDFEKVYTIGPVFRAEDSNTHRHMTEFVGLDLEM 323

  Fly   324 AFKYHYHEVLHTIGNTFTSIFKGLRDKYAKEIESVGQQYKVDAFKFLEPPLILQFADGVAMLREA 388
            ||.:|||||:.||....|.:||||:..|..||.:||.||..:.|:|.||||||::.|.:.:|||.
Worm   324 AFNFHYHEVMETIAEVLTQMFKGLQQNYQDEIAAVGNQYPAEPFQFCEPPLILKYPDAITLLREN 388

  Fly   389 GVETGDEEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLAIRPFYTMPDPNNPVYSNSYDMFMRGE 453
            |:|.|||:|||||.||.||:|||.||.||||:||||||::||||||||.::..||||||||||||
Worm   389 GIEIGDEDDLSTPVEKFLGKLVKEKYSTDFYVLDKFPLSVRPFYTMPDAHDERYSNSYDMFMRGE 453

  Fly   454 EILSGAQRIHDPEYLIERAKHHGIDTSKIAAYIESFRYGCPPHAGGGIGMERVVMLYLGLDNIRK 518
            |||||||||||.:.|:||||||.:|.:||.:||:||:||||||||||||:|||.||:|||.|||.
Worm   454 EILSGAQRIHDADMLVERAKHHQVDLAKIQSYIDSFKYGCPPHAGGGIGLERVTMLFLGLHNIRL 518

  Fly   519 TSMFPRDPKRLTP 531
            .|:||||||||||
Worm   519 ASLFPRDPKRLTP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS	NP_001260930.1	PLN02850	49..531	CDD:215456	305/486 (63%)
		AspRS_cyto_N	89..187	CDD:239815	52/97 (54%)
		AsxRS_core	203..527	CDD:238399	230/323 (71%)
dars-1	NP_499089.1	PLN02850	4..531	CDD:215456	324/531 (61%)
		AspRS_cyto_N	84..182	CDD:239815	52/97 (54%)
		AsxRS_core	204..527	CDD:238399	230/322 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167920
Domainoid	1	1.000	485	1.000	Domainoid score	I194
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1032
Inparanoid	1	1.050	639	1.000	Inparanoid score	I448
Isobase	1	0.950	-	0	Normalized mean entropy	S293
OMA	1	1.010	-	-		QHG60941
OrthoDB	1	1.010	-	-		D267439at33208
OrthoFinder	1	1.000	-	-		FOG0004194
OrthoInspector	1	1.000	-	-		oto20381
orthoMCL	1	0.900	-	-		OOG6_100778
Panther	1	1.100	-	-	LDO	PTHR43450
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1432
SonicParanoid	1	1.000	-	-		X2940
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790