Protein Alignment AspRS and DARS1

DIOPT Version :10

• Sequence 1: NP_476609.1
• Gene: AspRS / 36420
• FlyBaseID: FBgn0002069
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001340.2
• Gene: DARS1 / 1615
• HGNCID: 2678
• Length: 501
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 337/509 - (66%)
• Similarity: 408/509 - (80%)
• Gaps: 11/509 - (2%)

  Fly    23 AKAAKKAEQKAENASTAAANNAGGDSAEDHAAGRYGLSEMIQSKDKRSERNFVPVSELSGQVGKG 87
            |.|::|:::|.....         |:|||:|..|||:|.||||::| .:|..|.|.:|:.|....
Human     4 ASASRKSQEKPREIM---------DAAEDYAKERYGISSMIQSQEK-PDRVLVRVRDLTIQKADE 58

  Fly    88 LVWVRGRVHTSRAKGKQCFLILRQQSSTVQCILAVGDVISKQMVKFAGNIPKESIIDIQAKPVAV 152
            :||||.||||||||||||||:||||...||.::||||..||||||||.||.||||:|::.....|
Human    59 VVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKV 123

  Fly   153 SSKIESCTEQSLELSVEQIFVISQAKAQLPLQIEDASRPENADDAEGLNIRVNQDTRLDNRVLDL 217
            :.||.|||:|.:||.|::|:|||.|:.:||||::||.|||...:.|| ...|||||||||||:||
Human   124 NQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEG-RATVNQDTRLDNRVIDL 187

  Fly   218 RTPANQAIFRLEAGVCRLFRDILTEQGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQL 282
            ||..:||:|||::|:|.|||:.|..:||.||.||||||||||||||||||||||::|||||||||
Human   188 RTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQL 252

  Fly   283 YKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGL 347
            ||||.|.|||:||:::|.||||||||||||||||||||:||||.||||||:..|.:|...|||||
Human   253 YKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGL 317

  Fly   348 RDKYAKEIESVGQQYKVDAFKFLEPPLILQFADGVAMLREAGVETGDEEDLSTPNEKLLGRLVKA 412
            ::::..||::|.:|:..:.||||||.|.|::.:.:|||||||||.|||:|||||||||||.|||.
Human   318 QERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKE 382

  Fly   413 KYDTDFYILDKFPLAIRPFYTMPDPNNPVYSNSYDMFMRGEEILSGAQRIHDPEYLIERAKHHGI 477
            |||||||||||:|||:|||||||||.||..|||||||||||||||||||||||:.|.|||.||||
Human   383 KYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGI 447

  Fly   478 DTSKIAAYIESFRYGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 531
            |..||.|||:|||:|.|||||||||:|||.||:|||.|:|:|||||||||||||
Human   448 DLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AspRS	NP_476609.1	PLN02850	49..531	CDD:215456	330/481 (69%)
DARS1	NP_001340.2	PLN02850	3..501	CDD:215456	335/507 (66%)
		Aspartate. /evidence=ECO:0000250	251..254		2/2 (100%)
		Binding site for the 3'-end of tRNA. /evidence=ECO:0000255	411..415		1/3 (33%)