DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AspRS and Dars1

DIOPT Version :9

Sequence 1:	NP_001260930.1	Gene:	AspRS / 36420	FlyBaseID:	FBgn0002069	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_446251.1	Gene:	Dars1 / 116483	RGDID:	621167	Length:	501	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	336/509 - (66%)
Similarity:	404/509 - (79%)	Gaps:	11/509 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AKAAKKAEQKAENASTAAANNAGGDSAEDHAAGRYGLSEMIQSKDKRSERNFVPVSELSGQVGKG 87
            |.|::|.::|.....         |:|||:|..|||:|.||||::| .:|..|.|.:|:.|....
  Rat     4 ANASRKGQEKPREIV---------DAAEDYAKERYGVSSMIQSQEK-PDRVLVRVKDLTVQKADE 58

  Fly    88 LVWVRGRVHTSRAKGKQCFLILRQQSSTVQCILAVGDVISKQMVKFAGNIPKESIIDIQAKPVAV 152
            :||||.||||||||||||||:||||...||.::||||..||||||||.||.||||||::.....|
  Rat    59 VVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGIVRKV 123

  Fly   153 SSKIESCTEQSLELSVEQIFVISQAKAQLPLQIEDASRPENADDAEGLNIRVNQDTRLDNRVLDL 217
            :.||.|||:|.:||.|::|:|||.|:.:||||::||.|||...:.:| ...||||||||||::||
  Rat   124 NQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDG-RATVNQDTRLDNRIIDL 187

  Fly   218 RTPANQAIFRLEAGVCRLFRDILTEQGFTEIHTPKIISAASEGGANVFTVSYFKDSAYLAQSPQL 282
            ||..:||||.|::|:|.|||:.|..:||.||.||||||||||||||||||||||.:|||||||||
  Rat   188 RTSTSQAIFHLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKSNAYLAQSPQL 252

  Fly   283 YKQMAIAADFDKVYTVGAVFRAEDSNTHRHLTEFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGL 347
            ||||.|.|||:||:.:|.||||||||||||||||||||:||||.||||||:..|.:|...|||||
  Rat   253 YKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGL 317

  Fly   348 RDKYAKEIESVGQQYKVDAFKFLEPPLILQFADGVAMLREAGVETGDEEDLSTPNEKLLGRLVKA 412
            ::::..||::|.:|:..:.||||||.|.|::.:.:|||||||||..||||||||||||||||||.
  Rat   318 QERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKE 382

  Fly   413 KYDTDFYILDKFPLAIRPFYTMPDPNNPVYSNSYDMFMRGEEILSGAQRIHDPEYLIERAKHHGI 477
            |||||||:|||:|||:|||||||||.||..|||||||||||||||||||||||:.|.|||.||||
  Rat   383 KYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGI 447

  Fly   478 DTSKIAAYIESFRYGCPPHAGGGIGMERVVMLYLGLDNIRKTSMFPRDPKRLTP 531
            |..||.|||:|||:|.|||||||||:|||.||:|||.|:|:|||||||||||||
  Rat   448 DLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AspRS	NP_001260930.1	PLN02850	49..531	CDD:215456	329/481 (68%)
		AspRS_cyto_N	89..187	CDD:239815	63/97 (65%)
		AsxRS_core	203..527	CDD:238399	238/323 (74%)
Dars1	NP_446251.1	PLN02850	20..501	CDD:215456	329/482 (68%)
		AspRS_cyto_N	60..158	CDD:239815	63/97 (65%)
		AsxRS_core	174..497	CDD:238399	238/322 (74%)
		Aspartate. /evidence=ECO:0000250	251..254		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354543
Domainoid	1	1.000	500	1.000	Domainoid score	I334
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1032
Inparanoid	1	1.050	673	1.000	Inparanoid score	I697
OMA	1	1.010	-	-		QHG60941
OrthoDB	1	1.010	-	-		D267439at33208
OrthoFinder	1	1.000	-	-		FOG0004194
OrthoInspector	1	1.000	-	-		oto96920
orthoMCL	1	0.900	-	-		OOG6_100778
Panther	1	1.100	-	-	LDO	PTHR43450
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2940
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770