Protein Alignment INSM1 and Insm1

DIOPT Version :10

• Sequence 1: NP_002187.1
• Gene: INSM1 / 3642
• HGNCID: 6090
• Length: 510
• Species: Homo sapiens
• Sequence 2: NP_058585.2
• Gene: Insm1 / 53626
• MGIID: 1859980
• Length: 521
• Species: Mus musculus
• Alignment Length: 523
• Identity: 474/523 - (90%)
• Similarity: 480/523 - (91%)
• Gaps: 15/523 - (2%)

Human     1 MPRGFLVKRSKKSTPVSYRVRGGEDGDRALLLSPSCGGARAEPPAPSPVPGPLPPPPP---AERA 62
            |||||||||||||||||||||||||.||||||||.|||||||||.||  |||||||||   ||||
Mouse     1 MPRGFLVKRSKKSTPVSYRVRGGEDSDRALLLSPGCGGARAEPPVPS--PGPLPPPPPPALAERA 63

Human    63 HAALAAALACAPG-PQPPPQGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPV 126
            ||||||||||||| |.|||.|||||||||||||||||||||||||||||||||||||||||||||
Mouse    64 HAALAAALACAPGPPPPPPPGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPV 128

Human   127 SAESFPTPAALL-GGGGGGGASGAGGGGTCGGDPLLFAPAELKMGTAFSAGAEAARGPGPGPPLP 190
            |||||||||||| |||.|...:|.|||||||||.|||||||||||||||||||||||||.||||.
Mouse   129 SAESFPTPAALLAGGGSGANGAGGGGGGTCGGDALLFAPAELKMGTAFSAGAEAARGPGTGPPLS 193

Human   191 PAAALRPPGKRPPPP--TAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAP 253
            ||||||||||||.||  .|.||||||.|||.||||||||||||||||||||||||||||||||||
Mouse   194 PAAALRPPGKRPAPPAAVATEPPAKAAKAPSAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAP 258

Human   254 RGRAGGAARPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHK 318
            |||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   259 RGRAGGATRPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHK 323

Human   319 PRPAPAAARAPEPEAAARAEAREAPGGG-SDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYL 382
            |||.||||||||||||.|||||||.||| ||||||||||||||||||||||||||||||||||||
Mouse   324 PRPVPAAARAPEPEAATRAEAREAAGGGSSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYL 388

Human   383 RKHLLAHHQALQAKGA-----PLAPPAEDLLALYPGPDEKAPQEAAGDGEGAGVLGLSASAECHL 442
            ||||||||||||||||     |..|||||:||.|.||||||||||:||||.||||||||:|:|||
Mouse   389 RKHLLAHHQALQAKGAPPPPPPPPPPAEDILAFYAGPDEKAPQEASGDGEAAGVLGLSATAQCHL 453

Human   443 CPVCGESFASKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVR 507
            ||||||:|.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   454 CPVCGETFPSKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVR 518

Human   508 PAC 510
            |||
Mouse   519 PAC 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INSM1	NP_002187.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..110		101/112 (90%)
		SNAG domain. /evidence=ECO:0000250|UniProtKB:Q63ZV0	1..20		18/18 (100%)
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269|PubMed:23721412	2..7		4/4 (100%)
		Necessary for interaction with CCND1	43..58		11/14 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..226		42/51 (82%)
		C2H2 Zn finger	269..289	CDD:275368	19/19 (100%)
		C2H2 Zn finger	297..317	CDD:275368	19/19 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..362		43/47 (91%)
		zf-C2H2	367..389	CDD:395048	21/21 (100%)
		C2H2 Zn finger	369..389	CDD:275368	19/19 (100%)
		C2H2 Zn finger	443..464	CDD:275368	18/20 (90%)
		C2H2 Zn finger	471..492	CDD:275368	20/20 (100%)
Insm1	NP_058585.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		53/59 (90%)
		SNAG domain. /evidence=ECO:0000305|PubMed:24227653	1..20		18/18 (100%)
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250|UniProtKB:Q01101	2..7		4/4 (100%)
		Necessary for interaction with CCND1. /evidence=ECO:0000250	43..56		11/14 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..107		27/30 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..230		40/49 (82%)
		C2H2 Zn finger	274..294	CDD:275368	19/19 (100%)
		C2H2 Zn finger	302..322	CDD:275368	19/19 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..369		44/48 (92%)
		zf-C2H2	373..395	CDD:395048	21/21 (100%)
		C2H2 Zn finger	375..395	CDD:275368	19/19 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..419		13/20 (65%)
		C2H2 Zn finger	454..475	CDD:275368	18/20 (90%)
		C2H2 Zn finger	482..503	CDD:275368	20/20 (100%)