DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmda1 and grinaa

DIOPT Version :9

Sequence 1:	NP_523722.1	Gene:	Nmda1 / 36419	FlyBaseID:	FBgn0013305	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001038775.1	Gene:	grinaa / 724005	ZFINID:	ZDB-GENE-060616-231	Length:	363	Species:	Danio rerio

Alignment Length:	345	Identity:	153/345 - (44%)
Similarity:	207/345 - (60%)	Gaps:	33/345 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PQYPQYQDPNQQYNYGGGNPPQGGYGGY-PPQGGYPPQGPPQG---------YP--PYAQGGAQP 59
            |:...:..|...|:.|.|.||....|.| ||..|.|..|.|..         ||  ||.|   .|
Zfish    25 PKTDAFGMPPPNYSQGPGAPPYAAPGTYGPPDYGQPAYGQPPAPGFGPGPGPYPQMPYPQ---MP 86

  Fly    60 YPQP-YGQGP-PPGGYAPQPGFIQP----PPSAG----GYGAYDDPESQPKNFSF-----DDQSI 109
            |||. |.||| |...|...||  ||    .|:|.    ||...|.|.|...|..|     :|:||
Zfish    87 YPQANYAQGPYPQSPYQQGPG--QPAFGVDPNASMESPGYHGGDGPPSYYGNDDFANSNWEDKSI 149

  Fly   110 RRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRR 174
            ||.|||||:::|..||:|||..|.:|.:.:..|.|.|.|.|.::|:..:..|:::.::||..|||
Zfish   150 RRAFIRKVFMVLTVQLLVTFSFVTVFTFAKDAKVFVRRNQWTYYVSYAIFFVSLIVLSCCGEVRR 214

  Fly   175 QTPTNFIFLGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILI 239
            :.|.|.:.|.:.|.:.|:|:|:.|:.|....|:||||||..||.|:.:|:||||||||...|:|:
Zfish   215 KHPWNLVALSILTLSLSYLVGMIASFYDTDAVIMAVGITVVVCFAVVVFSLQTKYDFTSCYGVLL 279

  Fly   240 ACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMMGGEHKYSISPEEYIFAALNL 304
            .|.:|.|:..|:.||::.||:.:||||:|||||:.:|..||||::|.: |.:||||||:||||||
Zfish   280 VCTIVLLVACILCIFIRNKILHIVYASLGALLFTCFLAVDTQLLLGNK-KLAISPEEYVFAALNL 343

  Fly   305 YLDIINIFMYILTIIGASRD 324
            |.||||||:|||.|:|.:||
Zfish   344 YTDIINIFLYILAIVGRTRD 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmda1	NP_523722.1	LFG_like	103..320	CDD:198410	108/221 (49%)
grinaa	NP_001038775.1	Pro-rich	<23..131	CDD:291893	39/110 (35%)
		Bindin	82..>133	CDD:251078	22/55 (40%)
		LFG_like	143..359	CDD:198410	107/216 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41517
Inparanoid	1	1.050	268	1.000	Inparanoid score	I3002
OMA	1	1.010	-	-		QHG57711
OrthoDB	1	1.010	-	-		D1290306at2759
OrthoFinder	1	1.000	-	-		FOG0000200
OrthoInspector	1	1.000	-	-		mtm6588
orthoMCL	1	0.900	-	-		OOG6_100360
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X332
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880