DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmda1 and Grina

DIOPT Version :9

Sequence 1:	NP_523722.1	Gene:	Nmda1 / 36419	FlyBaseID:	FBgn0013305	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_075657.1	Gene:	Grina / 66168	MGIID:	1913418	Length:	345	Species:	Mus musculus

Alignment Length:	335	Identity:	151/335 - (45%)
Similarity:	212/335 - (63%)	Gaps:	31/335 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VPQYPQYQDPNQQYNYGGGNPPQGGYGGYP------PQGGYPPQGP-PQ-GYP--PYAQGGAQPY 60
            :|.|.|...|...|......|...|..|||      ||||| |||| || |||  ||.|   .|:
Mouse    26 MPPYVQAPYPGAPYPQAPFQPSPYGQPGYPHGPSPYPQGGY-PQGPYPQGGYPQGPYPQ---SPF 86

  Fly    61 -PQPYGQGPP---PGGYAPQPGFIQP--PPSAGGYGAYDDPESQPKNFSFDDQSIRRGFIRKVYL 119
             |.||||.||   ||  :||.|..|.  |||     .||:.:....|:   |::||:.|||||:|
Mouse    87 PPNPYGQPPPFQDPG--SPQHGNYQEEGPPS-----YYDNQDFPAVNW---DKNIRQAFIRKVFL 141

  Fly   120 ILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIFLG 184
            :|..||.||...||:|.:....|.|.|.|:|.::|:..:..::::.::||...||:.|.|.:.|.
Mouse   142 VLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALS 206

  Fly   185 LFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFG 249
            :.|.:.|:::|:.|:.|..:.|:||||||.|||..:.||::||:||||...|:|:..:||..||.
Mouse   207 ILTVSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFA 271

  Fly   250 IVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMMGGEHKYSISPEEYIFAALNLYLDIINIFMY 314
            |:.||::.:|:.:||||:|||||:.:|..||||::|.: :.|:|||||:|||||||.||||||:|
Mouse   272 ILCIFIRNRILEIVYASLGALLFTCFLAVDTQLLLGNK-QLSLSPEEYVFAALNLYTDIINIFLY 335

  Fly   315 ILTIIGASRD 324
            ||||||.:::
Mouse   336 ILTIIGRAKE 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmda1	NP_523722.1	LFG_like	103..320	CDD:198410	102/216 (47%)
Grina	NP_075657.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115		42/94 (45%)
		Pro-rich	<10..114	CDD:373673	41/93 (44%)
		LFG_like	128..341	CDD:198410	102/213 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	211	1.000	Domainoid score	I2789
eggNOG	1	0.900	-	-		E1_COG0670
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41517
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3079
Isobase	1	0.950	-	0	Normalized mean entropy	S1892
OMA	1	1.010	-	-		QHG57711
OrthoDB	1	1.010	-	-		D1290306at2759
OrthoFinder	1	1.000	-	-		FOG0000200
OrthoInspector	1	1.000	-	-		mtm8676
orthoMCL	1	0.900	-	-		OOG6_100360
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R158
SonicParanoid	1	1.000	-	-		X332
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.760