DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lfg and Tmbim1

DIOPT Version :9

Sequence 1:	NP_725236.1	Gene:	Lfg / 36418	FlyBaseID:	FBgn0025692	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_081430.3	Gene:	Tmbim1 / 69660	MGIID:	1916910	Length:	309	Species:	Mus musculus

Alignment Length:	246	Identity:	99/246 - (40%)
Similarity:	160/246 - (65%)	Gaps:	13/246 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YHYQQGDETGAYTDAEADKSF---AFDDQSIRKGFIRKVYLILMCQLLITFGFVSVFTFSKASQE 63
            |.:...:|..|.:|     ||   .:||:.:|..||:|||.|:..|||||...:::|||.:...:
Mouse    67 YGHDYNEEERAGSD-----SFRPGEWDDRKVRHSFIQKVYCIISVQLLITVAIIAIFTFVEPVGK 126

  Fly    64 WVQKNPALFWIALAVLIVTMICMACCESVRRKTPLNFIFLFLFTVAESFLLGMVAGQFEADEVLM 128
            :|:.|.|:::::.||.:||.:.:|||:..||:.|.|.|.|.:||:|..|:.|.::..:|...|::
Mouse   127 YVRNNVAVYYVSYAVFLVTYLTLACCQGPRRRFPWNIILLTIFTLALGFVTGTISSMYETKAVII 191

  Fly   129 AVGITAAVALGLTLFALQTKYDFTMCGGVLVACLVVFIIFGII-AIFIPGKVI---GLVYASLGA 189
            |:.|||.|::.:|:|..|||.|||.|.|:.....:|.::.||: :|.:..|.|   .:|||:|||
Mouse   192 AMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLMVTGIVTSIVLIFKYIYWLHMVYAALGA 256

  Fly   190 LLFSVYLVYDTQLMLGGNHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 240
            :.|:::|.|||||:| ||.|::||||:||..||.:|.||:.||.::|.::|
Mouse   257 ICFTLFLAYDTQLVL-GNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVG 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lfg	NP_725236.1	LFG_like	23..240	CDD:198410	92/220 (42%)
Tmbim1	NP_081430.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..84		6/21 (29%)
		LFG_like	87..306	CDD:198410	92/219 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0670
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57711
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000200
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100360
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R158
SonicParanoid	1	1.000	-	-		X332
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750