DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lfg and FAIM2

DIOPT Version :9

Sequence 1:	NP_725236.1	Gene:	Lfg / 36418	FlyBaseID:	FBgn0025692	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_036438.2	Gene:	FAIM2 / 23017	HGNCID:	17067	Length:	316	Species:	Homo sapiens

Alignment Length:	244	Identity:	109/244 - (44%)
Similarity:	159/244 - (65%)	Gaps:	8/244 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YQQGDETGAYTDAEADKSFAFDDQSIRKGFIRKVYLILMCQLLITFGFVSVFTFSKASQEWVQKN 68
            |..|..||   |.|...:|::|||.:|:.|:||||.||:.|||:|...|::|||....:::||.|
Human    76 YDNGFPTG---DHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQAN 137

  Fly    69 PALFWIALAVLIVTMICMACCESVRRKTPLNFIFLFLFTVAESFLLGMVAGQFEADEVLMAVGIT 133
            |..:|.:.||...|.:.:|||...||..|.|.|.|.:||::.::|.||::..:....||:.:|||
Human   138 PGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGIT 202

  Fly   134 AAVALGLTLFALQTKYDFTMCGGVLVACLVVFIIFG-IIAIFIPGKVI---GLVYASLGALLFSV 194
            |.|.|.:|:|:.|||:|||.|.|||...|:.....| |:||.:|.:.:   ..|||:|||.:|::
Human   203 ALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTL 267

  Fly   195 YLVYDTQLMLGGNHKYSISPEEYIFAALNLYLDIINIFMYILTIIGLSR 243
            :|..||||:: ||.::|:|||||||.|||:|||||.||.:.|.:.|.:|
Human   268 FLALDTQLLM-GNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNR 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lfg	NP_725236.1	LFG_like	23..240	CDD:198410	100/220 (45%)
FAIM2	NP_036438.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
FAIM2	NP_036438.2	LFG_like	92..312	CDD:198410	100/220 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0670
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57711
OrthoDB	1	1.010	-	-		D1290306at2759
OrthoFinder	1	1.000	-	-		FOG0000200
OrthoInspector	1	1.000	-	-		mtm8436
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R158
SonicParanoid	1	1.000	-	-		X332
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860