DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and SLC22A14

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_006713479.2	Gene:	SLC22A14 / 9389	HGNCID:	8495	Length:	675	Species:	Homo sapiens

Alignment Length:	563	Identity:	146/563 - (25%)
Similarity:	259/563 - (46%)	Gaps:	61/563 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCR---VPELEPWTQDYVQ 64
            |..:|..||.||.:|:.::....:|:.: .||..::..|:....:.:|.   :..:.|......|
Human   133 FANLLDAVGEFGTFQQRLVALTFIPSIM-SAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQ 196

  Fly    65 LVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVVPCQHGW 129
            |  ||:||:..||::..|.|             |.|.|    ...:.:::...:.|..  ||.||
Human   197 L--NLTIPQAPNGSFLTCFM-------------YLPVP----WNLDSIIQFGLNDTDT--CQDGW 240

  Fly   130 HYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAYLLLEII 194
            .|..: ...:::.|::|||........|.::|..|..:|:.:|..:.|..||.|:....||..||
Human   241 IYPDA-KKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLII 304

  Fly   195 ACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGLVVLAG 259
            ....:||..:::.:|..||.:..:|.....|...||.|.:..|.|....|:.:..:::|.|:|.|
Human   305 FGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTG 369

  Fly   260 VIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRVNRDFV 324
            :.|.:..|:.|.|...:.::...|..::|||||||||..||.:.|.::|...|.||...:..:.:
Human   370 IAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLL 434

  Fly   325 ERLQ--RKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAPALG 387
            :.||  ||.| |||:           :||..:...:.:.||:::.:||..:..|..||.....||
Human   435 DELQLPRKKV-TRAS-----------VLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELG 487

  Fly   388 GDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD------------ 440
            ....:...:...:|:|..|.....|...||:|.|.:::|...:.|:.....|:
Human   488 VSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRC 552

  Fly   441 -------ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMG 498
                   :|:|:..:.:..::::..|..|..:||.|||:|..|:...|:.|:.|.|:  .:..:.
Human   553 PATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAIL--SLTIIS 615

  Fly   499 QQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAV 541
            |...:||:.:...|.|:....|.||||||::.|.::|.....:
Human   616 QTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQI 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	110/416 (26%)
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	142/545 (26%)
SLC22A14	XP_006713479.2	MFS	270..641	CDD:119392	102/384 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940