DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and SLC22A8

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001171661.1	Gene:	SLC22A8 / 9376	HGNCID:	10972	Length:	542	Species:	Homo sapiens

Alignment Length:	561	Identity:	186/561 - (33%)
Similarity:	276/561 - (49%)	Gaps:	75/561 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVP---ELEPWTQDY 62
            |.|.|:|..|||.|.:|.:.:..:.|| .|..|.|...|:|.||||.|.||.|   ...||.
Human     1 MTFSEILDRVGSMGHFQFLHVAILGLP-ILNMANHNLLQIFTAATPVHHCRPPHNASTGPWV--- 61

  Fly    63 VQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVV-PCQ 126
                    :|...||....|             |.:..||:         ..|..||.:.: ||.
Human    62 --------LPMGPNGKPERC-------------LRFVHPPN---------ASLPNDTQRAMEPCL 96

  Fly   127 HGWHYDKSIYSST---VVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAY 188
            .||     :|:||   :|.||:|||:.:.|..:|..:|..|.|:|..|.|.|.|.:||||.....
Human    97 DGW-----VYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCS 156

  Fly   189 LLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLG 253
            .||...:.:.:||:..:..::..||:.|..:..|..|..:|.:|.|....|...:......|:.|
Human   157 YLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFG 221

  Fly   254 LVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVR 318
            ..:|.|:.|.:..||.|.|.||:|..:.|...:..|||.|||:..||:.:|:|||:.:|..||.:
Human   222 QFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK 286

  Fly   319 VNRDFVE------RLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYV 377
            ...:.:.      .||:::.:.:|..|.|         ||||.|.:||.|..::|.|||     .
Human   287 EEGERLSLEELKLNLQKEISLAKAKYTAS---------DLFRIPMLRRMTFCLSLAWFA-----T 337

  Fly   378 GLSYYAPALGGDEIW-NFFLA----GAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVA-TF 436
            |.:||:.|:|.:|.. |.::.    |.|::|...:....|||.||......::|:.|.|.:| ||
Human   338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTF 402

  Fly   437 LYPD---ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMG 498
            :..|   :..:|...||..:||||..|.|..|||||||:|..||..|::.:.||.:|.|::...|
Human   403 VPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITG 467

  Fly   499 QQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGE 539
            :....:|.|:.|...:|||.|:|.||||.|:.||:|:|:.|
Human   468 EVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLE 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	138/413 (33%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	178/544 (33%)
		MFS	96..493	CDD:119392	138/415 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153802
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.980