DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Balat and SLC22A6

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens

Alignment Length:	562	Identity:	173/562 - (30%)
Similarity:	265/562 - (47%)	Gaps:	63/562 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPE---------LE 56
            |.|:::|::||..|.:|::.:..|:||..| .|.|...|.|.||.|.|.||.|.         ||
Human     1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLL-MASHNTLQNFTAAIPTHHCRPPADANLSKNGGLE 64

  Fly    57 PWTQDYVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPP----PDLLRQQAEDLLKLQP 117
            .|            :||:|.|....|             |.:..|    |.|...:|.
Human    65 VW------------LPRDRQGQPESC-------------LRFTSPQWGLPFLNGTEAN------- 97

  Fly   118 DTTQVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRR 182
            .|....||..||.||.|.:.||:|.||:|||....|..||..::.||.|||..|||||.|..|||
Human    98 GTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRR 162

  Fly   183 PSFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSN 247
            .......|...::...:|||.|:..:...|.:.|:.:..|..:...|.:|.:....|.....:..
Human   163 KVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIG 227

  Fly   248 IAYSLGLVVLAGVIYIVRDWRELSLAVSMPL--LMLFSCFFVLPESPRWLMAVGKTRRAIKILKV 310
            ..||||..:||||.|.|..||.|.|.||.|.  ..::|.||:  ||.||..:.|:....::.|:.
Human   228 YVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFI--ESARWHSSSGRLDLTLRALQR 290

  Fly   311 MARVNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYG---ILDLFRGPNMRRKTLIITLIWFAN 372
            :||:||.|     .|..:..:.:.||:..| .:|...|   .::|.|.|.:|...|.::::|||.
Human   291 VARINGKR-----EEGAKLSMEVLRASLQK-ELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

  Fly   373 TSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFL 437
            :..|.||.......|........:.|||:||..|:.:..::..|||.....::|:.|:..:...:
Human   350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGV 414

  Fly   438 YPD----ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMG 498
            .|.    :...|..:||..:::||..:.|...|||||::|..||...|.::.||.||.|:::...
Human   415 IPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTA 479

  Fly   499 QQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEA 540
            :....:||.:.||:.:.....::|||||..:.||.|:::.|:
Human   480 ELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	127/404 (31%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	167/544 (31%)
		MFS	135..505	CDD:119392	113/377 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.980