DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a7

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	163/556 - (29%)
Similarity:	265/556 - (47%)	Gaps:	47/556 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQL 65
            |.|:::|.:||.||.:|...:..:.||..| ...|....:|:||.|.|.|.:|. .|....:..|
  Rat     1 MGFEDLLDKVGGFGPFQLRNLVLMALPRML-LPMHFLLPVFMAAVPAHHCALPG-APANLSHQDL 63

  Fly    66 VKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLL---------RQQAEDLLKLQPDTTQ 121
            .....:||..:|:::.|          :|:...:..|::.         ..:.|.|
  Rat    64 WLEAHLPRETDGSFSSC----------LRFAYPQTVPNVTLGTEVSNSGEPEGEPL--------- 109

  Fly   122 VVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFY 186
            .|||..||.||:|.:|||:..||:|||.:..|..:....|.:|.|:|..|:|||.|.:|||....
  Rat   110 TVPCSQGWEYDRSEFSSTIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLL 174

  Fly   187 AYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYS 251
            ...:..::....||.:.||..::..|.:.|..:.........|.:|.:..|.|....::|.:.:|
  Rat   175 VAYVSSLVLGLMSAASINYIMFVVTRTLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTVFWS 239

  Fly   252 LGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNG 316
            .|:::||.|.|::|.||.|.||.::|.:......:.:|||.|||:..|:...|.|.|...|::||
  Rat   240 GGVLLLALVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNG 304

  Fly   317 VRVNRDFV--ERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGL 379
            ..|....:  |.|...:.:.||.:..|       .|||||...:|..:|...::||.....|.||
  Rat   305 RPVGEGSLSQEALNNVVTMERALQRPS-------YLDLFRTSQLRHISLCCMMVWFGVNFSYYGL 362

  Fly   380 SYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD---- 440
            :.....||.:......|.||||||:.::::..:...||| :....||:|......|.|...
  Rat   363 TLDVSGLGLNVYQTQLLFGAVELPSKIMVYFLVRRLGRR-LTEAGMLLGAALTFGTSLLVSLETK 426

  Fly   441 --ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLV 503
              ||.|: .|||....::|....|..|||||||:|..|:..::::..:|..:.|:...:....|:
  Rat   427 SWITALV-VVGKAFSEAAFTTAYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLL 490

  Fly   504 LPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGE 539
            ||.:..|.:.::....:||||||:...||:|:::.|
  Rat   491 LPKVAYGGIALVAACTALLLPETKKAQLPETIQDVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	123/403 (31%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	157/539 (29%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	109/375 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850