DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Balat and Slc22a8

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	180/559 - (32%)
Similarity:	271/559 - (48%)	Gaps:	75/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVP---ELEPWTQDY 62
            |.|.|:|..|||.|.:|.:.:..:.|| .|..|.|...|:|.|.||.|.||.|   .:.||.
  Rat     1 MTFSEILDRVGSMGPFQYLHVTLLALP-VLGIANHNLLQIFTATTPVHHCRPPPNASIGPWV--- 61

  Fly    63 VQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQ--VVPC 125
                    :|.:.||...:|          :|:: :.|...|            |:.||  ..||
  Rat    62 --------LPLDPNGKPEKC----------LRFV-HLPNASL------------PNDTQRATEPC 95

  Fly   126 QHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSF-YAYL 189
            ..||.|:.:  ..|:|.||:|||..:.|..:|..:|..|.|:|..|.|.|.|.:||:|.. ::||
  Rat    96 LDGWIYNST--RDTIVIEWDLVCSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYL 158

  Fly   190 LLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGL 254
            :|......| ||:.:...::..||:.|.::..|..|..:|.:|.|....|...:......|::|.
  Rat   159 MLAASGSGA-AFSPSLPVYMIFRFLCGCSISGISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQ 222

  Fly   255 VVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRV 319
            .:|:|:.|.:..||.|.|..|.|..:.....:.:|||.|||:..||..:|:|.|:.:|..||.:.
  Rat   223 FILSGLAYAIPQWRWLQLTSSAPFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKKE 287

  Fly   320 NRDFVERLQRKLVITRAAETK-------SSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYV 377
            .       .:||.|   .|.|       :|....||:.||||...:||.|..::|.||:     .
  Rat   288 E-------GKKLTI---EELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFS-----T 337

  Fly   378 GLSYYAPALGGDEIW-NFFLA----GAVELPTYLLLWPGLSYFGRRWI-LFISMLVGGVACVATF 436
            |.:||:.|:|.:|.. |.::.    |.|::|...:....|||.|||.. .|:.:|.||......|
  Rat   338 GFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSLSYLGRRITQSFLLLLAGGAILALIF 402

  Fly   437 LYPDITLL---LYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMG 498
            :..::.||   |...||..:|.||..|.|..|||||||:|..||..|:|.:.||.::.|::...|
  Rat   403 VPSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNVWARVGSMIAPLVKITG 467

  Fly   499 QQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEE 537
            :....:|.::.|...:|||.|:..|.||.||.||:|:|:
  Rat   468 ELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLPETIED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	134/412 (33%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	173/544 (32%)
		MFS	124..492	CDD:119392	123/383 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950