DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Balat and slc22a21

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001295487.1	Gene:	slc22a21 / 799908	ZFINID:	ZDB-GENE-091118-62	Length:	546	Species:	Danio rerio

Alignment Length:	561	Identity:	165/561 - (29%)
Similarity:	286/561 - (50%)	Gaps:	41/561 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQLV 66
            |::|....:|::|.:||.:. |:|..:.:|..|...|.:|:..||.|.||:||....|..:
Zfish     5 DYEEQTAFLGAWGPFQKTVF-SLLCLSIIPNGFTGLSIVFLGDTPAHHCRIPETLNLTAGW---- 64

  Fly    67 KNLSIPRNRNGAYAECSMYSRNYTDIVR-YLEYRPPPDLLRQQAEDLLKLQPDTTQVVP---CQH 127
            :|.|:||.:.......|...|...|:|: |.:....|.|....:|            :|   |..
Zfish    65 RNASVPRPQPHGDPRASRCYRLRLDLVKNYSDGGLLPGLDVNVSE------------IPREECAD 117

  Fly   128 GWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAYLLLE 192
            ||.|||.|||||:|.||:|||...:...|...:|..|.|.|:.:.|.:.|.:||:...:..:.::
Zfish   118 GWIYDKEIYSSTIVSEWDLVCSDDWKSPLTSSIFFCGVLTGSVISGPVSDRFGRKIVLFVTMAIQ 182

  Fly   193 IIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPE-RRVFCTIVSNIAYSLGLVV 256
            .:......|:.::..:..|.|:||:...:...:.:||.:|::... |.|:.|:...:.:|:|.::
Zfish   183 TLFTVVQVFSPSWQIFCFLFFIVGMGQISNYVAAFVLGMEILSSSVRDVYSTLGVCLFFSIGYMI 247

  Fly   257 LAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRVNR 321
            |....:.:||||.|.||:::|.......::.:|||||||::.|:.:.|..|::..|::|.|.. .
Zfish   248 LPLAAFFLRDWRSLMLALTIPGFFYIPLWWFIPESPRWLLSQGRVQEAEAIIRKAAKINRVTA-P 311

  Fly   322 DFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAPAL 386
            |.:      ..:.::.|....:.: :.:.:|.:..|:|..|.::.|||.|.:..|..||....:|
Zfish   312 DVI------FPLMQSTEDAGGVQS-FSVCELLKSSNIRYMTGLLCLIWMAVSIGYCALSLNTSSL 369

  Fly   387 GGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD----ITLLLYC 447
            .|:...|..|:..||:|..|:.|..|....||..|..::.:||:..:...|.|:    :||.|..
Zfish   370 HGNIYLNCLLSAVVEVPALLMAWLMLRLAPRRHCLASTLALGGLVLLLILLIPEDQSSVTLALVM 434

  Fly   448 VGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLVLPLIVMGAL 512
            :||.|:|::|.::..:.:||||||:|...:...|:.|.||.|..|..|::|.....||.|::|.:
Zfish   435 LGKFGLSAAFSIIYPVTAELYPTVLRNTALGACSMSSRVGGISAPYFNYLGSYHRSLPYILIGGI 499

  Fly   513 LILGGFASLLLPETRNRNLPQTLEEGEAV-------PLSFL 546
            .:|.|..|.||||:|...||:|:.:.:.|       ||:.:
Zfish   500 NVLSGLLSFLLPESRGSALPETIGQMQTVKGLKKHSPLNII 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	121/400 (30%)
slc22a21	NP_001295487.1	2A0119	14..521	CDD:273328	159/531 (30%)
slc22a21	NP_001295487.1	MFS	146..511	CDD:119392	105/372 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588449
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.960