DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Balat and oct2

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001107932.1	Gene:	oct2 / 797890	ZFINID:	ZDB-GENE-080204-92	Length:	554	Species:	Danio rerio

Alignment Length:	576	Identity:	178/576 - (30%)
Similarity:	287/576 - (49%)	Gaps:	58/576 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDEVLREVGSFGLYQKVIICSVL--LPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQ 64
            :|||:|:..|.||.|||.|  |||  ||..| .||.....:|:..||.|:|:...|:.......:
Zfish     3 NFDELLQHAGDFGFYQKRI--SVLGSLPILL-LAFVLIGVVFLGYTPDHWCKTASLQEKCGFSEE 64

  Fly    65 LVKNLSIPR-NRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQA--EDLLKLQPDTTQVVPCQ 126
            .|::|::|| ...||:::|..:.                |.||..:  ...:.:..::|.:..|.
Zfish    65 QVRDLTVPRTGARGAFSKCVKFD----------------DALRNGSALSCNISIFNNSTHLSACN 113

  Fly   127 HGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAYLLL 191
            .||.::::  .:|:|.|::|||:.|:|..|..|....|..:|..|.|||.|.:||:..|.|.:..
Zfish   114 EGWTFNEN--RTTIVTEFSLVCEDSWLADLNQVSLAGGFFIGALVTGYLADRFGRKSCFIASIFG 176

  Fly   192 EIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGLVV 256
            ..::.....|:..|...|..|.:.|........:.|||.||..|...|.|.:::|...||||||:
Zfish   177 LGVSGTCIIFSPYYPLLLFFRCLQGFFAKGAWTATYVLIIEFFGSNNRKFVSVMSRTFYSLGLVL 241

  Fly   257 LAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRVNR 321
            |..:.|.:..||.|.||:::|..:.....:|:|||||||::..||:.|:.|:|.:|:.|...:..
Zfish   242 LPALAYYIPSWRNLQLAMTLPTFIFLIYHWVIPESPRWLLSQRKTKEALSIVKSIAKCNKRSLPE 306

  Fly   322 DFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAPAL 386
            ||.|   ..|:|.:..|.   |...|  .|||:.|.||:.|.|:...||....|:.||.......
Zfish   307 DFHE---MDLLIEKQEEI---MRPSY--KDLFKTPKMRKHTFILIYAWFTGAVVFQGLVLRLGIT 363

  Fly   387 GGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVAT-FLYPDITLL---LYC 447
            |.:...:|.::..|||||.|:.:..:...|||.::.....:||.||:|. |:.|:|:.|   :..
Zfish   364 GDNVFLDFLISAVVELPTGLIFYFLVDRIGRRPLMATVNFIGGAACLAVPFISPNISWLRRTIAI 428

  Fly   448 VGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINH-MGQQMLVLPLIVMGA 511
            ||::.::.....:....:|||||.:|.||:|..|..|.:|.:|.|.|.: :......|||:|.|.
Zfish   429 VGRLAVAIGNETVNFANTELYPTPLRNLGVSVCSSASDIGAVVAPFILYRLASIWQELPLLVYGV 493

  Fly   512 LLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPNNIRASPKKR 567
            :.:|.....:||||.:..:||:|:::.|                   |:|:..|::
Zfish   494 MSVLYSGLVMLLPEMKGVDLPETVDDVE-------------------NLRSRHKRK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	131/400 (33%)
oct2	NP_001107932.1	2A0119	12..516	CDD:273328	169/532 (32%)
oct2	NP_001107932.1	MFS	123..506	CDD:119392	129/390 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.850