DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Balat and slc22a7a

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001077330.1	Gene:	slc22a7a / 794188	ZFINID:	ZDB-GENE-050506-52	Length:	560	Species:	Danio rerio

Alignment Length:	610	Identity:	190/610 - (31%)
Similarity:	294/610 - (48%)	Gaps:	86/610 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLP-AALPCAFHAYSQLFIAATPQHFCRVPELE-------P 57
            |.|::||||:|.|..:|.:::..:.|| ..||..|..::  ||:..|.|.|.:|.|:       .
Zfish     1 MRFEDVLREIGGFNKFQFLVLYILWLPRVILPLHFLLHN--FISGVPPHHCALPRLDGRFSASGA 63

  Fly    58 WTQDYVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQV 122
            ..::..|:|. |.||||.:|:|:.|.||:.             |.|.  ....||..|..:.:.|
Zfish    64 EKEELAQIVA-LGIPRNSDGSYSSCKMYTM-------------PMDF--DLNGDLSVLYGNRSNV 112

  Fly   123 -VPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRP--- 183
             ||||:||.||:|.::||...||:||||...|.......|.:|..:|..|||.|.|.:||:|
Zfish   113 SVPCQNGWVYDRSQFTSTTATEWDLVCDNKKLNQALATFFFIGVTMGAVVFGQLSDKFGRKPMIQ 177

  Fly   184 -SFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSN 247
             ||.:..:..||    .||:.:|..:...|.:.|..:..:..:...|.:|....:.|.|...:.:
Zfish   178 VSFVSSAVFGII----EAFSSSYVMFAIARTLCGFALTGMSITTVALCVEWTDVKHRTFTGTIIS 238

  Fly   248 IAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMA 312
            :.:|:|.::||.:.|::||||.|.|.|:.|.|:....::.:|||.|||:|.|:...|.|.|...|
Zfish   239 LGWSVGNMLLALLAYLIRDWRHLILVVTSPCLVGIIAWWWIPESARWLLANGRVEEAQKYLINCA 303

  Fly   313 RVNGVRVNRDFVERLQ----RKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANT 373
            ::||   ...:.::|.    :|:.|   ||..:.   ::..|||.|.|.:|:..|...:.|||..
Zfish   304 KMNG---KYSYTKKLDIENLKKITI---AEDSNK---NHSYLDLVRTPKLRKIVLCSGIFWFAVA 359

  Fly   374 SVYVGLSYYAPALGGDEIWNFFLAGAVELP----TYLLLWPGLSYFGRR----WILFISMLVGGV 430
            ..|.|:|:.....|.:.....|:.|.:|:|    |||.    |...|||    |.|.|:..:.|:
Zfish   360 FTYYGISFNITGFGLNIYLTQFIYGVIEVPAKVGTYLT----LDRIGRRNGQAWSLIIAGALIGL 420

  Fly   431 ACVATFLYPDITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPM-- 493
            ..|....:..:...:..:||....::|.:..|..|||||||:|..|:.::|.|:.:|..:.||
Zfish   421 NSVIPTEFAAVRTGIAVIGKGFSEAAFTIAFLYTSELYPTVLRQCGLGYTSFIARIGGSLAPMVI 485

  Fly   494 ----INHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTL---EEGEAVPLSFLLCCCV 551
                |.|.|      |.:|..|..:..|....|||||.|..||:.:   |||... ||      .
Zfish   486 LFEDIWHYG------PPVVFSATAVFSGCVVFLLPETTNVQLPENILDVEEGRHT-LS------T 537

  Fly   552 ESER--KPNNIRASPKKRILPEAGT 574
            |:||  :.|.:.:.|..  |.|.|:
Zfish   538 EAERDVELNEMNSGPAD--LQEKGS 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	127/417 (30%)
slc22a7a	NP_001077330.1	2A0119	11..523	CDD:273328	170/552 (31%)
slc22a7a	NP_001077330.1	MFS	148..514	CDD:119392	113/388 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589030
Domainoid	1	1.000	86	1.000	Domainoid score	I8032
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880