DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Balat and SLC22A5

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001295051.1	Gene:	SLC22A5 / 6584	HGNCID:	10969	Length:	581	Species:	Homo sapiens

Alignment Length:	575	Identity:	178/575 - (30%)
Similarity:	289/575 - (50%)	Gaps:	69/575 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDEVLREVGSFGLYQKVIICSVLLPAA-LPCAFHAYSQLFIAATPQHFCRVPEL----EPWTQD 61
            |:|||...:|.:|.:|::|.  .||.|: :|..|...|.:|:.|||:|.||||:.    ..|
Human     3 DYDEVTAFLGEWGPFQRLIF--FLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAW--- 62

  Fly    62 YVQLVKNLSIP-RNRNGAYAECSMYSRNYTDIVRY--LEYRPPPDLLRQQAEDLLKLQPDTTQVV 123
                 :|.::| |.|:|.....|........|..:  |...|..|:      ||.:|:.::
Human    63 -----RNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDV------DLGQLEQES---- 112

  Fly   124 PCQHGWHYDKSIYSSTVVQE------------------------WNLVCDRSFLVTLALVVFGVG 164
             |..||.:.:.:|.||:|.|                        |||||:..:...|.:.:|.||
Human   113 -CLDGWEFSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVG 176

  Fly   165 GLLGNYVFGYLVDLWGRRPSFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVL 229
            .|||:::.|.|.|.:||:...:..:.::........|:.|:..::.|..:||:...:...:.:||
Human   177 VLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVL 241

  Fly   230 AIELVGPE-RRVFCTIVSNIAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPR 293
            ..|::|.. |.:|.|:...|.|:.|.:||....|.:||||.|.:|::||.::..:.::.:|||||
Human   242 GTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPR 306

  Fly   294 WLMAVGKTRRAIKILKVMARVNGVRVNRDFVE--RLQRKLVITRAAETKSSMTTHYGILDLFRGP 356
            ||::.|:...|..|::..|:.||:.|.....:  .||         :..|.....:.||||.|..
Human   307 WLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQ---------DLSSKKQQSHNILDLLRTW 362

  Fly   357 NMRRKTLIITLIWFANTSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWIL 421
            |:|..|::..::|...:..|.|||...|.|.||...|.||:..||:|.|:|.|..|.|..||:.:
Human   363 NIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSM 427

  Fly   422 FISMLVGG-VACVATFLYPDITLL---LYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSV 482
            ..::.:|| |......:.||:..|   |..|||.|::::|.::.:..:||||||||.:|:..||.
Human   428 ATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSST 492

  Fly   483 ISMVGPIVIPMINHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEE 537
            .|.:|.|:.|...::|.....||.|:||:|.||....:|.|||:....||.|:::
Human   493 ASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQ 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	134/426 (31%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	173/561 (31%)
SLC22A5	NP_001295051.1	MFS	162..534	CDD:119392	122/380 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153731
Domainoid	1	1.000	74	1.000	Domainoid score	I9141
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8513
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.890