Protein Alignment Balat and SLC22A4

DIOPT Version :10

• Sequence 1: NP_610823.1
• Gene: Balat / 36417
• FlyBaseID: FBgn0033778
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 185/569 - (32%)
• Similarity: 295/569 - (51%)
• Gaps: 75/569 - (13%)

  Fly     2 DFDEVLREVGSFGLYQKVIICSVLLPAA-LPCAFHAYSQLFIAATPQHFCRVPEL----EPWTQD 61
            |:|||:..:|.:|.:|::|.  .||.|: :|..|:..|.:|:|.||:|.||||:.    ..|
Human     3 DYDEVIAFLGEWGPFQRLIF--FLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAW--- 62

  Fly    62 YVQLVKNLSIP-RNRNGAYA--ECSMYSRNYTDIVRY--LEYRPPPDLLRQQAEDLLKLQPDTTQ 121
                 :|.|:| |.|:|...  .||.|  ....|..:  |...|..|:      ||.:|:.::
Human    63 -----RNNSVPLRLRDGREVPHSCSRY--RLATIANFSALGLEPGRDV------DLGQLEQES-- 112

  Fly   122 VVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFY 186
               |..||.:.:.:|.||||.||||||:.::.|.|...:|.||.|||::|.|.|.|.:||:...:
Human   113 ---CLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLF 174

  Fly   187 A-------YLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPE-RRVFCT 243
            |       :..|:|.     :.:|..:|.|.:  :||:...:.....::|..|::|.. |.:|.|
Human   175 ATMAVQTGFSFLQIF-----SISWEMFTVLFV--IVGMGQISNYVVAFILGTEILGKSVRIIFST 232

  Fly   244 IVSNIAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKIL 308
            :.....:::|.::|....|.:||||.|.||:::|.::....::.:|||||||::..:.|.|..|:
Human   233 LGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDII 297

  Fly   309 KVMARVNGVRVNR---DFVERL----QRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIIT 366
            :..|::|.:.|..   |.||.|    |:|..                ||||||..|:...|::..
Human   298 QKAAKMNNIAVPAVIFDSVEELNPLKQQKAF----------------ILDLFRTRNIAIMTIMSL 346

  Fly   367 LIWFANTSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVA 431
            |:|...:..|..||..||.|.||...|.||:..:|:|.|:..|..|....||:|:...:..||..
Human   347 LLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGV 411

  Fly   432 CVATFLYP----DITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIP 492
            .:...|.|    .:::.|..:||.||:|:|.:|.:..:|||||:||.:.:..:|..|.||.|:.|
Human   412 LLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP 476

  Fly   493 MINHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAV 541
            ...::|....:||.||||:|.:|.|..:|..||:....||:|||:.:.|
Human   477 YFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKV 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	136/414 (33%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	177/551 (32%)