Protein Alignment Balat and SLC22A2

DIOPT Version :9

• Sequence 1: NP_610823.1
• Gene: Balat / 36417
• FlyBaseID: FBgn0033778
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 174/558 - (31%)
• Similarity: 278/558 - (49%)
• Gaps: 55/558 - (9%)

  Fly     4 DEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVP---ELE---PWTQDY 62
            |:||...|.|..:||.:...:.|.:|.....:. ..:|:..||.|.||.|   ||.   .|: ..
Human     6 DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYV-GIVFLGFTPDHRCRSPGVAELSLRCGWS-PA 68

  Fly    63 VQLVKNLSIPRNRNGAYA---ECSMYSRNYT----DIVRYLEYRPPPDLLRQQAEDLLKLQPDTT 120
            .:|  |.::|.......|   :|..|..::.    |.|                :.|..|..:.:
Human    69 EEL--NYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCV----------------DPLASLDTNRS 115

  Fly   121 QVV--PCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRP 183
            ::.  ||:.||.|:..  .|::|.|:||||..|:::.|......||..:|:...||:.|.:||:.
Human   116 RLPLGPCRDGWVYETP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKL 178

  Fly   184 SFYAYLLLEIIACAASAFAWNYYTW-LGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSN 247
            .....:|:...|....|.: ..||| |..|.:.||...|.....|:|..|.||...|....|...
Human   179 CLLTTVLINAAAGVLMAIS-PTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQ 242

  Fly   248 IAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMA 312
            :||::||:|||||.|.:..||.|...||:|.......::.:|||||||::..|...|::|:|.:|
Human   243 VAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIA 307

  Fly   313 RVNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYV 377
            :.||    :.....|||   :....||...:...:  |||.|.|.:|:.|:|:...||.::.:|.
Human   308 KKNG----KSLPASLQR---LRLEEETGKKLNPSF--LDLVRTPQIRKHTMILMYNWFTSSVLYQ 363

  Fly   378 GLSYYAPALGGDEIW-NFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD- 440
            ||..:. .|.||.|: :||.:..||.|...::...:...|||:....|.:|.|.||:|:...|.
Human   364 GLIMHM-GLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGD 427

  Fly   441 ---ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIP-MINHMGQQM 501
               :.:::.|:|:|||:.::.::.|:.:|||||.:|.||:...|.:..:|.|:.| ::..:....
Human   428 LQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIW 492

  Fly   502 LVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGE 539
            |.|||:|.|.|.::.|...||||||:.:.||:|:||.|
Human   493 LELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAE 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	133/402 (33%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	167/544 (31%)
		MFS	124..492	CDD:119392	123/380 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850