Protein Alignment Balat and SLC22A1

DIOPT Version :9

• Sequence 1: NP_610823.1
• Gene: Balat / 36417
• FlyBaseID: FBgn0033778
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 169/599 - (28%)
• Similarity: 271/599 - (45%)
• Gaps: 110/599 - (18%)

  Fly     4 DEVLREVGSFGLYQK---VIICSVLLPAALP--CAFHAYSQLFIAATPQHFCRVPELEPWTQ--- 60
            |::|.:||..|.:||   :|:|  ||.||..  |.    ..:|:..||.|.|:.|.:...:|
Human     5 DDILEQVGESGWFQKQAFLILC--LLSAAFAPICV----GIVFLGFTPDHHCQSPGVAELSQRCG 63

  Fly    61 --DYVQLVKNLSIPRNRNGAYA---ECSMYSRNYTDIVRYLEYRPPPDLLRQQA----EDLLKLQ 116
              ...:|  |.::|.......|   :|..|..::                .|.|    :.|..|.
Human    64 WSPAEEL--NYTVPGLGPAGEAFLGQCRRYEVDW----------------NQSALSCVDPLASLA 110

  Fly   117 PDTTQVV--PCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLW 179
            .:.:.:.  |||.||.||..  .|::|.|:||||..|:.:.|.......|.|.|:...||..|.:
Human   111 TNRSHLPLGPCQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRF 173

  Fly   180 GRRPSFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTI 244
            ||:......:|:..::....||:.||.:.|..|.:.||.......:.|.|..|.||...|....|
Human   174 GRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAI 238

  Fly   245 VSNIAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILK 309
            :..:|:::|||.|.|:.|.:..||.|.||||:|..:....::.:|||||||::..:...||||:.
Human   239 MYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMD 303

  Fly   310 VMARVNG---------VRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLII 365
            .:|:.||         :.:..|..|:|.....                  ||||.|.:|::|.|:
Human   304 HIAQKNGKLPPADLKMLSLEEDVTEKLSPSFA------------------DLFRTPRLRKRTFIL 350

  Fly   366 TLIWFANTSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGV 430
            ..:||.::.:|.||..:..|..|:...:|..:..||:|...:....:...||.:.:.:|.|:.|.
Human   351 MYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGA 415

  Fly   431 AC-VATFLYPD---ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVI 491
            || |..|:.||   :.:::.|||:|||:.:..::.|:.:|||||.||.||:...|.:..:|.|:.
Human   416 ACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT 480

  Fly   492 P-MINHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESER 555
            | ::..:.:....||||:         |......:||                 |.|      ..
Human   481 PFIVFRLREVWQALPLIL---------FEKQSPKKTR-----------------FTL------RS 513

  Fly   556 KPNNIRASPKKRIL 569
            ||.|.|| |::.:|
Human   514 KPQNPRA-PERDVL 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	124/409 (30%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	154/539 (29%)
		MFS	118..484	CDD:119392	122/385 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153747
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950