DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Balat and slc22a16

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001020659.1	Gene:	slc22a16 / 557279	ZFINID:	ZDB-GENE-041001-166	Length:	565	Species:	Danio rerio

Alignment Length:	567	Identity:	162/567 - (28%)
Similarity:	267/567 - (47%)	Gaps:	58/567 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVP----ELEPWTQDYVQ 64
            :.:..|:|.|..:|..:..:.:. .|:.|..|..:.:|:..||:..|..|    ::
Zfish     6 ERLFDELGHFKRFQACLYFAAIF-QAISCGIHYLASVFLVETPKFLCNPPLNITDV--------- 60

  Fly    65 LVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQP------------ 117
            |.||||.               .:..||..:.:....|.::|....|..:|.|
Zfish    61 LYKNLSF---------------TSLADIWTHYKTGDGPVVVRTSQGDQWELSPCLKALRLDAINF 110

  Fly   118 -----DTTQVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVD 177
                 ....|..| ..:.||.|....::|.:|:|||:|.:|..|....|.:|.|:|..:||...|
Zfish   111 QYEFFGNKSVESC-GAFVYDHSEVEQSIVTDWDLVCEREWLAKLTQPTFMLGVLIGALMFGDAAD 174

  Fly   178 LWGRRPSFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFC 242
            ..||||...|..|.:.|.....||..|||.::.:||::.......|...:|...|..|.:.|.:.
Zfish   175 RIGRRPVLMATSLCQFIFGVTVAFTGNYYLFVVMRFLLATVSSGYLVVVFVYVTEFTGIKVRTWT 239

  Fly   243 TIVSNIAYSLGLVVLAGVIYIVRDW--RELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAI 305
            ::..:.|:::|::|:|.|.|:||.|  .::.|.:|....:|:...|  ||:|.:|||.|:.:.|.
Zfish   240 SMHVHAAFAVGIMVVALVGYLVRVWWIYQIILTLSTSPFLLYCWKF--PETPFYLMAKGRYKEAQ 302

  Fly   306 KILKVMARVNGVRVNRDFVERLQRKLVITRAAETKSSMTT--HYGILDLFRGPNMRRKTLIITLI 368
            ::|..||.:||:..... |..||.....|...:.|.:|..  ...:||:|....|..::.....|
Zfish   303 ELLDTMAYINGLPPTLK-VSDLQDGCDRTPLKDNKQAMEVEKRLSMLDMFGSLKMAGRSATCWAI 366

  Fly   369 WFANTSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACV 433
            ||..:..|...|..:..|||::..|.|||||||:|:||:....:..|||:.....::|:|||||:
Zfish   367 WFIGSLGYYVFSLGSVNLGGNQYINLFLAGAVEVPSYLIGCFAMDRFGRKKTCAPALLLGGVACM 431

  Fly   434 ATFLYPD----ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMI 494
            ...:.|.    :.::|...||..|:.:|.::.|...|||||::|.|.:...|::..||.:|.|..
Zfish   432 LIIVVPQDVEVLAIVLSMTGKFAIAIAFGLIYLYTCELYPTIIRSLAVGSGSMMCRVGSVVAPFC 496

  Fly   495 NHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAV 541
            .::....:.||.:::|.|..:.|..::.||||....|..||||.||:
Zfish   497 VYLADIWIYLPQLIVGILAFIIGILTMFLPETLGEPLTSTLEEAEAL 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	125/403 (31%)
slc22a16	NP_001020659.1	2A0119	13..536	CDD:273328	155/551 (28%)
slc22a16	NP_001020659.1	MFS	158..526	CDD:119392	114/370 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588818
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.880