DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and slc22a2

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	581	Identity:	173/581 - (29%)
Similarity:	286/581 - (49%)	Gaps:	60/581 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEP------WTQD 61
            |:|:|.|.|:||..|..|.|:..| .::|.:|.....:|...||:|:||.|.:..      |:
Zfish     4 FEEILEEAGTFGRSQIRIFCTFCL-VSIPFSFVYVGIVFQGFTPEHWCRDPGVSEIRERCGWS-- 65

  Fly    62 YVQLVKNLSIP--RNRNGA-YAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVV 123
             :|..:..::|  ...:|| |::|..:..::.......| .|..|..:.|    |.:.|    ::
Zfish    66 -LQDARRATVPLINGSSGASYSQCGRFDVDWNATGLSCE-NPDGDFNQSQ----LSVMP----MM 120

  Fly   124 PCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYA- 187
            .|..||.|| .:...:.|.|::|||..::.|.:......:|.|:|:...|||.|.:||..||..
Zfish   121 SCVDGWEYD-YVGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMT 184

  Fly   188 --YLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAY 250
              ::.:..|..|.|.   ||.:.|..|.:.|..|.......|||..||||.:.|....:...:.:
Zfish   185 NFFIGVTGILVATSP---NYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQLFF 246

  Fly   251 SLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVN 315
            |:|:::|..:.|.:.:||.|.:..::|.:...:.::.:|||||||:...|...|::|.|.:|:.|
Zfish   247 SMGILLLPLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKEN 311

  Fly   316 GVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLS 380
            .        :.|.:|:...:.....|..|..:  :|||:...:|..|.|::..||.:..||.||.
Zfish   312 R--------KTLSKKIETLKDDNIDSGSTASF--MDLFKTAKLRTYTFILSFNWFTSAVVYQGLI 366

  Fly   381 YYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD----I 441
            .....|||:...:|.::|.||||...|:...:...|||.....:.:|.|.||:.|...||    :
Zfish   367 MRLGILGGNVYVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACLITAFIPDSMFWL 431

  Fly   442 TLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIP-MINHMGQQMLVLP 505
            ...:.|||::||:.:|.::..:.:||||||:|.||:|..|.:..||.||.| ::..:....|.||
Zfish   432 KSAVACVGRLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELP 496

  Fly   506 LIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPNNIRASPKK 566
            ||:.|||..:.|...||||||:...||:|:::.|                .||..:.:|::
Zfish   497 LIIFGALAFVAGGLVLLLPETKGVPLPETIDDIE----------------HPNRNKENPQQ 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	128/403 (32%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	164/539 (30%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	119/381 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.850