DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and SLC22A

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	160/551 - (29%)
Similarity:	267/551 - (48%)	Gaps:	44/551 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEVLREVGSFGLYQKVI---ICSVLLPAALPCAFHA---YSQLFIAATPQHFCRVPELEPWTQDY 62
            |.:|:.:|.||.:|.:|   ||       ||..|||   .:.:|.|||..|.|.|.|.:....:|
  Fly    28 DAILKHLGQFGRFQLIIFLLIC-------LPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNY 85

  Fly    63 VQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVVPCQH 127
            .:...|.|||:|... ...|:.|:.  :::.::           ..:.|:......|.....|.|
  Fly    86 YEPHTNWSIPKNGKD-LDSCNRYTN--SELPQW-----------NHSVDICSADHFTKNKEACAH 136

  Fly   128 GWHYDKSIYSS---TVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAYL 189
                ::.::..   |:..::.:.||..:.:::...:..:|...|..:.|::.|.:||..|.....
  Fly   137 ----NEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGG 197

  Fly   190 LLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGL 254
            :|..:.....:|:.:|..:|...|:..:|...:.::.:|:.||||||:|||....|..:.|::|.
  Fly   198 ILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGE 262

  Fly   255 VVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRV 319
            |:||.......|||.|......|.|:|.:.|::||||.|||::.||..||..||:..|.||
  Fly   263 VLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVN---- 323

  Fly   320 NRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAP 384
            .|:..|.:..|||:....:.:.|..:.:.|.:.|:  |.:.:....:|.|..:..||.|||....
  Fly   324 KRELPESVLDKLVLANRDKLQQSSESRFPIREAFK--NFKWRIANCSLCWIVHVLVYYGLSLNVV 386

  Fly   385 ALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFL----YPDITLLL 445
            .|.||:..||.....||:|.:.:....:..||||:.|...||..|:.|:.|..    .|.:.|:|
  Fly   387 LLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVL 451

  Fly   446 YCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLVLPLIVMG 510
            :.|||:.|::||.||...|||:|||.:|...:||.|::...|.::.|....:.:.....|.::..
  Fly   452 FLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPAMLFA 516

  Fly   511 ALLILGGFASLLLPETRNRNLPQTLEEGEAV 541
            ...|:.|..:|..|||.|..||.|::|.:|:
  Fly   517 GAAIVSGLLTLFFPETTNVVLPTTVQEADAI 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	117/402 (29%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	155/535 (29%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	117/389 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458524
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.990