DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and slc22a4

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_989323.1	Gene:	slc22a4 / 394948	XenbaseID:	XB-GENE-5858686	Length:	553	Species:	Xenopus tropicalis

Alignment Length:	571	Identity:	175/571 - (30%)
Similarity:	295/571 - (51%)	Gaps:	68/571 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDEVLREVGSFGLYQKVIICSVLLPAA-LPCAFHAYSQLFIAATPQHFCRVPE----LEPWTQD 61
            |:||....:|.:|.||.:|.  .||.|: :|..|:..|.:|:|..|:|.|.:||    ...|
Frog     3 DYDEATSFLGEWGRYQFMIF--FLLSASIIPNGFNGMSVMFLAGIPEHRCHIPESANLSAAW--- 62

  Fly    62 YVQLVKNLSIPRNRNGAYAECSMYS----RNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQV 122
                 :|.|||| ::|..::|..|.    .||:.:          .||..:..|:..::.:
Frog    63 -----RNASIPR-QDGQDSQCRRYRLGTLTNYSAL----------GLLPGRDVDVTGIEQE---- 107

  Fly   123 VPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYA 187
             ||..||:|.||:|.||:|.||::||:..:...|...:|.||.|||::|.|.|.|.:||:...:.
Frog   108 -PCLDGWNYSKSLYLSTIVTEWDIVCENDWKGPLTTSLFFVGVLLGSFVSGQLSDSFGRKKILFV 171

  Fly   188 YLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERR-VFCTIVSNIAYS 251
            .:.::........|:.::..:..|..:||:...:...:.::|..|::|...| :|.|:.:.|.::
Frog   172 TMAIQTGFSIVQVFSTSWEMFAILFLIVGMGQISNYVAAFILGTEILGKSARIIFSTLGTCIFFA 236

  Fly   252 LGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNG 316
            :|.::|....|.:||||.|.||:::|.|.....::::||||:||:..|:...|..|::..|::|.
Frog   237 IGYMMLPLFAYFIRDWRTLLLALTIPGLFCIPLWWIIPESPQWLICKGRLEEAEVIIRKAAKINR 301

  Fly   317 VRVN---------RDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFAN 372
            |...         .|..||.:|.                |.:|||.:..|:|..|::...:|...
Frog   302 VPAPAVIFKTTELEDIAERQKRS----------------YTLLDLVKTFNVRIITIMTVFLWLIT 350

  Fly   373 TSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFL 437
            :..|.|:|...|.|.||...|.||..|:|:|:.:..|..|.|..||:.:..|:|:|||..:...|
Frog   351 SIGYFGISLNTPNLHGDPFLNCFLLAAIEVPSNIFAWLLLRYISRRYSMCGSLLLGGVVLLLIQL 415

  Fly   438 YP-DITLL---LYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMG 498
            .| |:.:|   |..|||.|::::|.::.:..:||||||:|..|:...||.|.:|.::.|...::|
Frog   416 VPLDLQILSTVLVMVGKFGVTAAFSMVYVYTAELYPTVIRNTGVGIGSVSSRIGSVISPYFVYLG 480

  Fly   499 QQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCC 549
            ....:||.|:||:|.:..|...|..|||..:.||:|:|:.:::.   .|||
Frog   481 AYNRLLPYILMGSLTVANGILVLFFPETFGKPLPETIEQTQSIK---GLCC 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	128/409 (31%)
slc22a4	NP_989323.1	2A0119	12..516	CDD:273328	167/545 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110