DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and slc22a4

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	590	Identity:	171/590 - (28%)
Similarity:	281/590 - (47%)	Gaps:	62/590 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQLV 66
            |:|::...:|::|.:|..:..::.: :.||..|.....:|:..||.|.|.:||     |..:..|
Zfish     3 DYDDITSFLGTWGPFQLTVFLALAI-SILPNGFVGLYIVFVGDTPAHECLIPE-----QINISSV 61

  Fly    67 -KNLSIPRNRNGAYAECSMYSRNYTDIVR---YLEYRPPPDLLRQQAEDLLKLQPDTTQVVPCQH 127
             ::.:||........:.|..||...|.:|   .|.|.|..::...|.|           ..||..
Zfish    62 WRDAAIPTQMQDGVLKRSSCSRYRLDTLRQLSMLNYTPNVEVNLSQIE-----------TEPCVD 115

  Fly   128 GWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAYLLLE 192
            ||.|.:..|.||:|.||:|||:|.:...|...::..|.|:|.::.|.:.|.:||||..:..:.|:
Zfish   116 GWSYSQEFYQSTIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQ 180

  Fly   193 IIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGLVVL 257
            .|......|:.::..:..:.|.||.:..:.....|||..|::.|..||       :..|||:.:.
Zfish   181 TITILIQMFSPSWEVFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRV-------LFGSLGVFMG 238

  Fly   258 AGV--------IYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARV 314
            :|:        .|.:|.||.|.|..::..|:.|..::.:|||||||::.|:|..|..:|:..|..
Zfish   239 SGIGQMFFPLAAYFIRSWRWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEK 303

  Fly   315 NGVRVNRDFVERLQRKLVITRAAE----TKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSV 375
            |          |:....||..::|    .|..:..| .|||:....|.....||.:|:|...|..
Zfish   304 N----------RVTAPEVIFSSSEIEEAAKKRIQKH-SILDILSNCNAVSTILICSLLWMVITMS 357

  Fly   376 YVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYP- 439
            |..|......|.|:...||||:..||:|.|::....|.:..||.....::|:||.......|.|
Zfish   358 YYALILNTTNLHGNPYLNFFLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPT 422

  Fly   440 ---DITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQM 501
               .:...|..:||:.::::|.|:..:.|||:|||||.:.|...|:.:.:|.|:.|.|.::|...
Zfish   423 ELQGLATALEMLGKLCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYY 487

  Fly   502 LVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPNNIRASPKK 566
            ..:|.||:|.|.:..|..||||||::.:.||:|:.:.::|  ..|..|     |||.......|.
Zfish   488 RYIPYIVIGGLALFSGVMSLLLPESKGKVLPETIAQMQSV--RGLRRC-----RKPPAASTEDKS 545

  Fly   567 RILPE 571
            ::|.|
Zfish   546 KVLQE 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	125/411 (30%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	159/542 (29%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	112/383 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588479
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.990