DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and SLC22A10

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001034841.3	Gene:	SLC22A10 / 387775	HGNCID:	18057	Length:	541	Species:	Homo sapiens

Alignment Length:	580	Identity:	168/580 - (28%)
Similarity:	270/580 - (46%)	Gaps:	69/580 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWT------ 59
            |.|:|:|.:||..|.:|.:.:. .:||:.:....|...:.|.||.|.|.|.|..|:..|
Human     1 MAFEELLSQVGGLGRFQMLHLV-FILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGSGNET 64

  Fly    60 ----QDYVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTT 120
                :|   .:..:|||.:.|....:|..:            ..|...||..........:.||.
Human    65 GILSED---ALLRISIPLDSNLRPEKCRRF------------VHPQWQLLHLNGTIHSTSEADTE 114

  Fly   121 QVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSF 185
               ||..||.||:|.:.||:|.:|:||||...|.::...:...|.|:|..:.|::.|.:|||...
Human   115 ---PCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFIL 176

  Fly   186 YAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAY 250
            ...||...|....:|||..:..:..|||:.|.:...|:::..:...|.:.|..:....|:|:.|.
Human   177 RWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGAL 241

  Fly   251 SLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVN 315
            |:|.::|.|:.|:.|||:.|.:..|:|..:.|.....|.||.|||:...|....:|.|:.:||.|
Human   242 SIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTN 306

  Fly   316 GVR-----VNRDFV-ERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTS 374
            |::     :|.:.| ..:|.:|   .||:||::      :.||||.|:||::..|:..:.||||.
Human   307 GIKNAEETLNIEVVRSTMQEEL---DAAQTKTT------VCDLFRNPSMRKRICILVFLRFANTI 362

  Fly   375 VYVGLSYYAPALGGDEIWNFFLA----GAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVA- 434
            .:.|.......:|.    |.||.    |||.|....|....|::.|||....:.|.:.|::.:|
Human   363 PFYGTMVNLQHVGS----NIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILAN 423

  Fly   435 TFLYPDITLLLYCVGKMGISSSFVVLPLMA---SELYPTVVRGLGMSFSSVISMVGPIVIPMINH 496
            ||:..::..|...:..:||..|......:|   .||.|||:|..........|.:|..:.|::..
Human   424 TFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLMT 488

  Fly   497 MGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERK 556
            :......||.|:.|...|:||....|||||:|..||.|:::             ||:::|
Human   489 LTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKD-------------VENQKK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	124/409 (30%)
SLC22A10	NP_001034841.3	2A0119	11..526	CDD:273328	159/546 (29%)
SLC22A10	NP_001034841.3	MFS	143..516	CDD:119392	111/385 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153705
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940