DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a13

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001119757.1	Gene:	Slc22a13 / 316062	RGDID:	1306840	Length:	551	Species:	Rattus norvegicus

Alignment Length:	589	Identity:	187/589 - (31%)
Similarity:	293/589 - (49%)	Gaps:	60/589 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYV---- 63
            |.:|:.|||.||.:|..:...:.:|..| .||..:||:|:.....|:|.|    .|.:::.
  Rat     4 FAQVMAEVGDFGRFQVRLTILMGIPNFL-SAFFVFSQVFMVLDEAHYCSV----SWVKNHTFNLS 63

  Fly    64 ---QLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVVPC 125
               ||.  :|||.:..|....|.|             :|||||  ....||:|..:.:.||.  |
  Rat    64 AAEQLA--VSIPNDTAGRPESCLM-------------FRPPPD--NASLEDILSHRFNETQA--C 109

  Fly   126 QHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAYLL 190
            ..||.|.:: ...::..|::|||:|..|...:..||..|.|:|..|||.:.|..|||||....||
  Rat   110 DSGWDYPEN-RPPSLKNEFDLVCERENLKRTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQLL 173

  Fly   191 LEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGLV 255
            |..||..|:||..::..::.|||.:.......|.|..||..|.||..||....:::...::|||:
  Rat   174 LSGIASMATAFVSSFELYMTLRFALATANAGFLLSSNVLLSEWVGTSRRTRAMVLAQSNFALGLM 238

  Fly   256 VLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRVN 320
            .|||:.|.||:||.|.:..:.|:.:|...|:|||||||||::.|:|..|.::::..|.|||
  Rat   239 ALAGLAYGVRNWRLLQIIGTTPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNG---- 299

  Fly   321 RDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAPA 385
            |.....|..:||..:...:.::       |||||.|.:|:.|||:..:||.::.:|.||.:....
  Rat   300 RPLASELLNQLVPEKTGPSGNA-------LDLFRHPQLRKVTLILIAVWFVDSLLYYGLGFQVGD 357

  Fly   386 LGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFL----YPDITLLLY 446
            .|.|......:.|.||:|..|...|.:...||:|....::.:.||.||....    .|.:...|.
  Rat   358 FGLDIYLTQVIFGVVEVPARLSSIPMMEKLGRKWSQLCTLTLAGVMCVIIIFIPGDLPTVATALA 422

  Fly   447 CVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLVLPLIVMGA 511
            .|||...|::|.:..:..:||.||::|..||...|:.|.||.|:.|::..:.|....:|:::.|:
  Rat   423 VVGKFASSAAFTISYVYTAELLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPMLIFGS 487

  Fly   512 LLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPNNIRASPKKRILPEAGTPV 576
            |.|..|....||||||.:.|..||::             :|..:.|.:.:.:|:::.:..:|...
  Rat   488 LPIGAGLLCALLPETRGQTLKDTLQD-------------LEQGQPPRSYKTAPQRKDVEASGRTS 539

  Fly   577 FHRV 580
            ..||
  Rat   540 SARV 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	135/399 (34%)
Slc22a13	NP_001119757.1	2A0119	12..510	CDD:273328	175/533 (33%)
Slc22a13	NP_001119757.1	MFS	139..500	CDD:119392	126/371 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347219
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm9087
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950