DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a22

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001013969.1	Gene:	Slc22a22 / 299944	RGDID:	1304605	Length:	555	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	148/569 - (26%)
Similarity:	256/569 - (44%)	Gaps:	68/569 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQ--KVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYV 63
            |.|||:|..||..|.:|  .:::.::|   ::..:.|...:.|.||.|.|.|.|..|:. ::..:
  Rat     1 MAFDEILHHVGDRGRFQIWMIVVLNIL---SMVSSLHDVIENFTAAIPAHHCSVNLLDT-SRSEI 61

  Fly    64 QLVKNL--------SIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTT 120
            .:..||        |||...|....:|..:.......:       ..::....:.:|
  Rat    62 SMAMNLTTEAMMKVSIPMGPNQKPEQCRRFRHPQWQFI-------DSNISTSNSTEL-------- 111

  Fly   121 QVVPCQHGWHYDKSIYSSTVVQEWNLVCD-RSFLVTLALVVFGVGGLLGNYV----FGYLVDLWG 180
            :..||..||.||.|:::||:|.||:|||| :||.......     .|.|::|    .|.:.|.:|
  Rat   112 ETEPCLDGWTYDHSVFTSTIVTEWDLVCDFQSFKYYAQAT-----SLAGHFVAAPFCGIISDRFG 171

  Fly   181 RRP-SFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTI 244
            |:| ..|..|...|:. ...||..|:..:..|||:...:...:..:..:|.:|....:......:
  Rat   172 RKPLLMYCSLAYGILG-TCCAFVPNFSLYCVLRFLSSASASTVGMNCLILVLEETSVQWHATVIV 235

  Fly   245 VSNIAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILK 309
            :|.:..|.||..|.|:.|::.||..:.|..::|..:.|..|..:|||.||||..|||.:|:|.|:
  Rat   236 LSGLFSSTGLAGLGGLAYVLSDWHLIQLTSALPYFIFFILFCWVPESARWLMITGKTDQALKELQ 300

  Fly   310 VMARVNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTS 374
            .:|.:||   .:|..:.|..:.:.::..|...|...|:.|.|:...|.:|:..|..:.:.||...
  Rat   301 RIASING---KKDIAQNLTTEDLRSKVKEDVCSTVKHFSIKDIIINPMIRKIVLCYSSVLFAELF 362

  Fly   375 VYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYF------GRRWILFISMLVGGVACV 433
            ...||......||.:......|.|.:::|:     ..|:||      .|..|.|:....||...:
  Rat   363 SIFGLLLDVHMLGKNIFVTQILLGVIDIPS-----KSLTYFILRNVRRRPLIAFLLFATGGCITI 422

  Fly   434 ATFLYPD---ITLLLYCVGKMGISSSFV-VLPLMASELYPTVVR----GLGMSFSSVISMVGPIV 490
            ..||..|   :.|.::.:|| |..::|: :.....:||.|..:|    |:.:|.:.:.|::..:.
  Rat   423 TMFLSEDMYVLRLAIFILGK-GCFAAFISINTAYCNELSPVPLRSTLNGIYISVARLASVLSALT 486

  Fly   491 IPMINHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGE 539
            :....:    .::||:|..|.|.|:.......||||.|..:..|:::.|
  Rat   487 LVTRKY----FVLLPMIFCGVLPIVATINIYFLPETFNHPITDTIKDME 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	112/415 (27%)
Slc22a22	NP_001013969.1	2A0119	11..526	CDD:273328	140/552 (25%)
Slc22a22	NP_001013969.1	MFS	127..516	CDD:119392	107/407 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940