DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a5

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	171/547 - (31%)
Similarity:	281/547 - (51%)	Gaps:	37/547 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDEVLREVGSFGLYQKVIICSVLLPAA-LPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQL 65
            |:|||...:|.:|.:|::|.  .||.|: :|..|:..|.:|:|.||:|.|.||.    |.:....
  Rat     3 DYDEVTAFLGEWGPFQRLIF--FLLSASIIPNGFNGMSIVFLAGTPEHRCLVPH----TVNLSSA 61

  Fly    66 VKNLSIP-RNRNGAYAECSMYSRNYTDIVRY--LEYRPPPDLLRQQAEDLLKLQPDTTQVVPCQH 127
            .:|.||| ..::|.....|........|..:  |...|..|:      ||.:|:.:.     |..
  Rat    62 WRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDV------DLEQLEQEN-----CLD 115

  Fly   128 GWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAYLLLE 192
            ||.|:|.::.||:|.||:|||...:...|...:|.||.|:|:::.|.|.|.:||:...:..:.::
  Rat   116 GWEYNKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQ 180

  Fly   193 IIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPE-RRVFCTIVSNIAYSLGLVV 256
            ........|:.|:..:..|..:||:...:...:.:||..|::... |.:|.|:...|.|:.|.:|
  Rat   181 TGFSFLQLFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMV 245

  Fly   257 LAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRVNR 321
            |....|.:||||.|.||:::|.::..:.::.:|||||||::.|:.:.|..|::..|:.||:....
  Rat   246 LPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPS 310

  Fly   322 DFVE--RLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAP 384
            ...:  .||         :..|.....:.|.||.|..|:|..|::..::|...:..|.|||...|
  Rat   311 TIFDPSELQ---------DLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTP 366

  Fly   385 ALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD----ITLLL 445
            .|.||...|.||..|||:|.|:|.|..|.:..||:.:..::.:||...:...|.|.    ::..|
  Rat   367 NLHGDIYVNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELFYLSTAL 431

  Fly   446 YCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLVLPLIVMG 510
            ..|||.||:|::.::.:..:||||||||.:|:..||..|.:|.|:.|...::|.....||.|:||
  Rat   432 VMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMG 496

  Fly   511 ALLILGGFASLLLPETRNRNLPQTLEE 537
            :|.||....:|..||:....||.|:::
  Rat   497 SLTILTAILTLFFPESFGAPLPDTIDQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	129/402 (32%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	166/533 (31%)
		MFS	123..510	CDD:119392	125/395 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347300
Domainoid	1	1.000	71	1.000	Domainoid score	I9198
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860