DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a6

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	602	Identity:	174/602 - (28%)
Similarity:	278/602 - (46%)	Gaps:	85/602 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPE---------LE 56
            |.|:::|::||..|.:|.:.:..|:.|..| .|.|...|.|.||.|.|.||.|.         ||
  Rat     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLL-MASHNTLQNFTAAIPPHHCRPPANANLSKDGGLE 64

  Fly    57 PWTQDYVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRP---PPDLLRQQAEDLLKLQPD 118
            .|            :|.::.|....|..::            .|   ||.....:|.       .
  Rat    65 AW------------LPLDKQGQPESCLRFT------------SPQWGPPFYNGTEAN-------G 98

  Fly   119 TTQVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRP 183
            |....||..||.||.|.:.||:|.||||||.......||..::.||.|||..|||||.|..|||.
  Rat    99 TRVTEPCIDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRK 163

  Fly   184 SFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNI 248
            ......|...::...:|:|.||..:...|.:.|:::.:|..:...|.:|.:....|.:...:...
  Rat   164 VLILNYLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGY 228

  Fly   249 AYSLGLVVLAGVIYIVRDWRELSLAVSMP--LLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVM 311
            .||||..:|||:.|.|..||.|.|.||:|  :..::|.||:  ||.||..:.|:....::.|:.:
  Rat   229 VYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFFI--ESARWYSSSGRLDLTLRALQRV 291

  Fly   312 ARVNG---------VRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITL 367
            ||:||         :.|.|   ..||::|.:::...:         .::|.|.|.:|...|.:::
  Rat   292 ARINGKQEEGAKLSIEVLR---TSLQKELTLSKGQAS---------AMELLRCPTLRHLFLCLSM 344

  Fly   368 IWFANTSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVAC 432
            :|||.:..|.||.......|........:.|||:||...:.:..::..|||.....|:|:.|:..
  Rat   345 LWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICI 409

  Fly   433 VATFLYPD----ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPM 493
            :...:.|.    |...|..:||..::|||..:.|...||||||:|..|:...|.::.||.||.|:
  Rat   410 LVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPL 474

  Fly   494 INHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPN 558
            ::...:....:||.:.||:.::....:.|||||..:.||.|:::.::           .|..|.|
  Rat   475 VSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKS-----------RSRGKQN 528

  Fly   559 NIRASPKKRILP-EAGT 574
            ..:...:|:::| :|.|
  Rat   529 QQQQEQQKQMMPLQAST 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	126/410 (31%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	162/549 (30%)
		MFS	135..505	CDD:119392	112/383 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		8/43 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347427
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm9087
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950