DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a1

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	180/560 - (32%)
Similarity:	285/560 - (50%)	Gaps:	58/560 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEVLREVGSFGLYQK---VIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVP---ELEP---WT 59
            |:||.:||.||.:||   :::|  |:.|:|...:  ...:|:..||.|:|:.|   ||..   |:
  Rat     5 DDVLEQVGEFGWFQKQAFLLLC--LISASLAPIY--VGIVFLGFTPGHYCQNPGVAELSQRCGWS 65

  Fly    60 Q----DYVQLVKNLSIPRNRNGAYAECSMY----SRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQ 116
            |    :|.  |..|. |.:.....::|..|    :::..|.|                :.|..|.
  Rat    66 QAEELNYT--VPGLG-PSDEASFLSQCMRYEVDWNQSTLDCV----------------DPLSSLV 111

  Fly   117 PDTTQVV--PCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLW 179
            .:.:|:.  ||:|||.||..  .|::|.|:||||..::.|.|......:|..||:.|.||:.|.:
  Rat   112 ANRSQLPLGPCEHGWVYDTP--GSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRF 174

  Fly   180 GRRPSFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTI 244
            ||:.......|:..::...:|.|.:|.:.|..|.:.|:.......|.|.|..|.||...|....|
  Rat   175 GRKLCLLVTTLVTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAI 239

  Fly   245 VSNIAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILK 309
            :..:|:::|||.||||.|.:.|||.|.||||:|..:....::.:|||||||::..:|.||::|::
  Rat   240 LYQMAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIME 304

  Fly   310 VMARVNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTS 374
            .:|:.||.....|.     :.|.:...|..|.|.:    ..||||.||:|:.|:|:..:||:...
  Rat   305 QIAQKNGKVPPADL-----KMLCLEEDASEKRSPS----FADLFRTPNLRKHTVILMYLWFSCAV 360

  Fly   375 VYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYP 439
            :|.||..:..|.|.:...:||.:..||.|...::...:...||.:.:..|.||.|.||:.....|
  Rat   361 LYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIP 425

  Fly   440 D----ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIP-MINHMGQ 499
            .    :.:.|.|:|:||.:....::.|:.:|||||.:|.|||...|.:..:|.|..| |:..:.:
  Rat   426 HELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLME 490

  Fly   500 QMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGE 539
            ....||||:.|.|.:..|..:||||||:...||:|:||.|
  Rat   491 VWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	133/400 (33%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	172/546 (32%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	133/400 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm12320
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850