DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Balat and SV2C

DIOPT Version :9

Sequence 1:NP_610823.1 Gene:Balat / 36417 FlyBaseID:FBgn0033778 Length:604 Species:Drosophila melanogaster
Sequence 2:NP_055794.3 Gene:SV2C / 22987 HGNCID:30670 Length:727 Species:Homo sapiens


Alignment Length:640 Identity:121/640 - (18%)
Similarity:209/640 - (32%) Gaps:244/640 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 EYRPPPDLLRQQAEDLLKLQPDTTQVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVF 161
            |.|...:.|.||.|.:::         .|.||..            :|.|.    |::.:||:..
Human   126 ERRADEEELAQQYELIIQ---------ECGHGRF------------QWALF----FVLGMALMAD 165

  Fly   162 GV--------------------------------GGLLGNYVFGYLVDLWGRRPS---------F 185
            ||                                |.::|.:.:|.|.|..||:.|         |
Human   166 GVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGF 230

  Fly   186 YAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERR--------VFC 242
            :|:|         |:|...|..:|..|.:.|..:...:.:.:....|::..|:|        :|.
Human   231 FAFL---------SSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFW 286

  Fly   243 TI----VSNIAYSL----GLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVG 299
            .|    .|.:|:::    |.....|..|....||...:..::|.:........:|||||:|:.||
Human   287 MIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVG 351

  Fly   300 KTRRAIKILKVM----ARVNGVRVNRDFVERLQRKLVITRAAETKSS------------MTTHYG 348
            |...|..|||::    .|..|.......|.:::....|....|.:|.            .|..||
Human   352 KHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYG 416

  Fly   349 I----LDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAP----ALGGDE--------------- 390
            |    :..|..| :|..|:.:|::||..:..|.|||.:.|    .|..||               
Human   417 IWLTFMRCFNYP-VRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYAN 480

  Fly   391 -IWNFFLAGAV------------------------------------------------------ 400
             ..||.:...:                                                      
Human   481 FTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNT 545

  Fly   401 ELPTYLLL---WPGLSYFGRR--------------WILFI------------------------- 423
            :...|..:   :...|:|..:              ||.|:                         
Human   546 DFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRL 610

  Fly   424 -----SMLVGGVACVATFLY----PDITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSF 479
                 ||::.|::|.  ||:    ..:.:.:.|:......|::..|.::..|||||..|..|..|
Human   611 TMLGGSMVLSGISCF--FLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGF 673

  Fly   480 SSVISMVGPIVIPMINHMGQQMLV---LPLIVMGALLILGGFASLLLPETRNRNL 531
            .:.:.....::..:|  .|..:.:   :|:::...:|:.||...|.||:||.:.|
Human   674 LNALCKAAAVLGNLI--FGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVL 726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BalatNP_610823.1 MFS_SLC22 128..524 CDD:340875 108/600 (18%)
SV2CNP_055794.3 synapt_SV2 1..727 CDD:130366 121/640 (19%)
Interaction with SYT1. /evidence=ECO:0000250 1..57
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..84
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..128 1/1 (100%)
MFS 155..719 CDD:119392 105/581 (18%)
Pentapeptide_3 507..561 CDD:290309 1/53 (2%)
(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781 519..563 2/43 (5%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1933
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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