Protein Alignment Balat and SV2C

DIOPT Version :10

• Sequence 1: NP_610823.1
• Gene: Balat / 36417
• FlyBaseID: FBgn0033778
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_055794.3
• Gene: SV2C / 22987
• HGNCID: 30670
• Length: 727
• Species: Homo sapiens
• Alignment Length: 640
• Identity: 121/640 - (18%)
• Similarity: 209/640 - (32%)
• Gaps: 244/640 - (38%)

  Fly    97 EYRPPPDLLRQQAEDLLKLQPDTTQVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVF 161
            |.|...:.|.||.|.:::         .|.||..            :|.|.    |::.:||:..
Human   126 ERRADEEELAQQYELIIQ---------ECGHGRF------------QWALF----FVLGMALMAD 165

  Fly   162 GV--------------------------------GGLLGNYVFGYLVDLWGRRPS---------F 185
            ||                                |.::|.:.:|.|.|..||:.|         |
Human   166 GVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGF 230

  Fly   186 YAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERR--------VFC 242
            :|:|         |:|...|..:|..|.:.|..:...:.:.:....|::..|:|        :|.
Human   231 FAFL---------SSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFW 286

  Fly   243 TI----VSNIAYSL----GLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVG 299
            .|    .|.:|:::    |.....|..|....||...:..::|.:........:|||||:|:.||
Human   287 MIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVG 351

  Fly   300 KTRRAIKILKVM----ARVNGVRVNRDFVERLQRKLVITRAAETKSS------------MTTHYG 348
            |...|..|||::    .|..|.......|.:::....|....|.:|.            .|..||
Human   352 KHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYG 416

  Fly   349 I----LDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAP----ALGGDE--------------- 390
            |    :..|..| :|..|:.:|::||..:..|.|||.:.|    .|..||
Human   417 IWLTFMRCFNYP-VRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYAN 480

  Fly   391 -IWNFFLAGAV------------------------------------------------------ 400
             ..||.:...:
Human   481 FTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNT 545

  Fly   401 ELPTYLLL---WPGLSYFGRR--------------WILFI------------------------- 423
            :...|..:   :...|:|..:              ||.|:
Human   546 DFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRL 610

  Fly   424 -----SMLVGGVACVATFLY----PDITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSF 479
                 ||::.|::|.  ||:    ..:.:.:.|:......|::..|.::..|||||..|..|..|
Human   611 TMLGGSMVLSGISCF--FLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGF 673

  Fly   480 SSVISMVGPIVIPMINHMGQQMLV---LPLIVMGALLILGGFASLLLPETRNRNL 531
            .:.:.....::..:|  .|..:.:   :|:::...:|:.||...|.||:||.:.|
Human   674 LNALCKAAAVLGNLI--FGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVL 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	108/600 (18%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	121/640 (19%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..128		1/1 (100%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781	519..563		2/43 (5%)