DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a22

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_036015188.1	Gene:	Slc22a22 / 210463	MGIID:	2446114	Length:	587	Species:	Mus musculus

Alignment Length:	593	Identity:	154/593 - (25%)
Similarity:	255/593 - (43%)	Gaps:	96/593 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAF--HAYSQLFIAATPQHFCRV----------P 53
            |||||:|..||..|.:|   ||.::|...|....  |...:.|.||.|.|.|.:          .
Mouse     1 MDFDEILHHVGDSGRFQ---ICMIILLNILSLVLSPHDVLENFTAAIPAHHCSINLDNSRSEVST 62

  Fly    54 ELEPWTQDYVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPD 118
            ::...|:|.::    :|||...|....:|..:        ||.:::    .|..........:.:
Mouse    63 DMNLTTEDLMK----VSIPMGPNQKPEQCRRF--------RYTQWQ----FLDSNISTFNSTELE 111

  Fly   119 TTQVVPCQHGWHYDKSIYSSTVVQE---------------------------------WNLVCDR 150
            |.   ||..||.||.|:::||:|.|                                 |:||||.
Mouse   112 TE---PCLDGWTYDHSVFTSTIVTEGLSPPQPWDSDQYYHTKHEISPCEEGLKSSVKVWDLVCDF 173

  Fly   151 SFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRP-SFYAYLLLEIIA--CAASAFAWNYYTWLGLR 212
            ......|......|.|:...:.|.:.|.:||:| ..|..|....:.  |   |||.|:..:..||
Mouse   174 QSFKYYAQATSLAGHLVSCPLSGIISDRFGRKPLLMYCSLAYGAVGTYC---AFAPNFSVYCVLR 235

  Fly   213 FVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGLVVLAGVIYIVRDWRELSLAVSMP 277
            |::......||.:..:|.:|....:......::|.:..|:|..||.|:.|::.||..|.||.::|
Mouse   236 FLLSAFQSTILINSLILVLEEASVQWHPTIIVLSGLFNSIGQGVLGGLAYVISDWHLLQLAYALP 300

  Fly   278 LLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRVNRDFVERLQRKLVITRAAETKSS 342
            ..:.|..|..:|||.|||:..|||.:|.|.|:.:|.:||   .:...:.|..:.:.::..:..:|
Mouse   301 FFIFFVLFCWVPESVRWLIITGKTDQAWKELQRIASING---KKGIAQNLTTEDLRSKLKKDVNS 362

  Fly   343 MTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLL 407
            ....:.|.|:|..|.:|:..|..:.:.||....:|||......||.:........||:::|:
Mouse   363 TGKLFRIKDIFINPLIRKIVLSNSSLLFAELFSFVGLLLDVQLLGKNMFLTQIFLGAIDVPS--- 424

  Fly   408 LWPGLSYF------GRRWILFISMLVGGVACVATFLYPDITLL---LYCVGKMGISSSFVVLPLM 463
              ..|:||      .|..|.|:.:..|....:..|:..::.:|   ::.:||...::...:....
Mouse   425 --KSLTYFTIRNVSRRPLIAFLLLTTGSCITITIFISEEMYVLRTIIFILGKGCFAAFTCISTTY 487

  Fly   464 ASELYPTVVRG-LGMSFSSVISMVGPIVIPMINHMGQQMLV-LPLIVMGALLILGGFASLLLPET 526
            .:||.|..:|. |...|.:|:.:.|  |:..:....::..| ||:|:.|.|.|:...:.|.||||
Mouse   488 INELSPVELRSTLNGVFLAVVRLAG--VLSALTLATRKYFVYLPMILYGVLPIVATISILFLPET 550

  Fly   527 RNRNLPQT 534
              .|||.|
Mouse   551 --FNLPHT 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	112/442 (25%)
Slc22a22	XP_036015188.1	MFS_OAT	108..548	CDD:340932	115/455 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844068
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.940