DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a19

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	596	Identity:	176/596 - (29%)
Similarity:	290/596 - (48%)	Gaps:	65/596 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWT------ 59
            |.|.:::.::||.|.:|.:.:..||:..|| .|.|...:.|.||.|.|.|.||.|:..|
Mouse     1 MAFQDLIIQIGSLGRFQILHMIFVLICHAL-SAPHTLLENFTAAIPSHRCWVPILDNDTASDNGS 64

  Fly    60 ----QDYVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTT 120
                ||  .|:: :|||.:.|....:|.          ||::  |...||..........:|||.
Mouse    65 RILSQD--DLLR-ISIPLDSNLRPDKCR----------RYIQ--PQWHLLHLNGTFPTVTEPDTE 114

  Fly   121 QVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSF 185
               ||..||.||:|.:.||.|.:|:|||....|.::|..::..|..:|..:.|:|.|.:||:..|
Mouse   115 ---PCVDGWVYDQSTFLSTTVTQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRKLIF 176

  Fly   186 YAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAY 250
            ...||...|.....|||.::..:..|||:.|:....:..:..:|.:|...|:.:.....:..||.
Mouse   177 TCSLLKMAITETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALVMALIFIAS 241

  Fly   251 SLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVN 315
            .:|..:|.|:.:..|:|..|.||:|:|:.:|......|.||.|||:...|.::::|.||..|.||
Mouse   242 GVGQTLLGGLAFAFRNWHHLQLALSVPMFLLLIPTRWLSESARWLIMANKPQKSLKELKKAACVN 306

  Fly   316 GVRVNRDFVERLQRKLVIT------RAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTS 374
            .::.:.|   .|..::|.|      .||:||.|.      |||||.||:|::..:::.:.|.:..
Mouse   307 RIKNSGD---ALTLEVVKTIMKEELEAAQTKPSP------LDLFRTPNLRKRICLLSFVRFVSVM 362

  Fly   375 VYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVA-TFLY 438
            ..:||......|..:......|.|.|.:|..:|....::|.|||....|.|.|.|::.:| .||.
Mouse   363 SLLGLLINIQYLSNNVFLLQCLYGVVCIPANVLGNFSMNYMGRRMTQLIFMSVLGISILAVVFLP 427

  Fly   439 PDITLLLYCVGKMG--ISSSFVVLPLM-ASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQ 500
            .::.:|...:..:|  |||:.:...|: |:||.||::|...:....:....|..:.|::..:...
Mouse   428 QEMQILRVFLSTLGGAISSASITSTLVHANELVPTIIRATALGVVGIAGSAGGALSPLLMILTTY 492

  Fly   501 MLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPNNIRASPK 565
            ...||.|:.|.|..|||..:||||||:|:.||.::::             :|::||.:.   ..|
Mouse   493 SASLPWIIYGILPFLGGLVALLLPETKNQPLPDSIQD-------------IENKRKSSK---EAK 541

  Fly   566 KRILPEAGTPV 576
            |.::.:. ||:
Mouse   542 KDVVAKV-TPL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	122/405 (30%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	166/541 (31%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551		7/43 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844003
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940