DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a5

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_035526.1	Gene:	Slc22a5 / 20520	MGIID:	1329012	Length:	557	Species:	Mus musculus

Alignment Length:	551	Identity:	174/551 - (31%)
Similarity:	288/551 - (52%)	Gaps:	45/551 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDEVLREVGSFGLYQKVIICSVLLPAA-LPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQL 65
            |:|||...:|.:|.:|::|.  .||.|: :|..|:..|.:|:|.||:|.|.||.    |.:....
Mouse     3 DYDEVTAFLGEWGPFQRLIF--FLLSASIIPNGFNGMSIVFLAGTPEHRCLVPH----TVNLSSA 61

  Fly    66 VKNLSIP-RNRNGAYA--ECSMYS----RNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVV 123
            .:|.||| ..::|...  :|..|.    .|:::    |...|..|:      ||.:|:.::
Mouse    62 WRNHSIPLETKDGRQVPQKCRRYRLATIANFSE----LGLEPGRDV------DLEQLEQES---- 112

  Fly   124 PCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAY 188
             |..||.|||.::.||:|.||:|||...:...|...:|.||.|:|:::.|.|.|.:||:...:..
Mouse   113 -CLDGWEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLT 176

  Fly   189 LLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPE-RRVFCTIVSNIAYSL 252
            :.::........|:.|:..:..|..:||:...:...:.:||..|::... |.:|.|:...|.|:.
Mouse   177 MGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAF 241

  Fly   253 GLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGV 317
            |.:||....|.:||||.|.||:::|.::..:.::.:|||||||::.|:.:.|..|::..|::||:
Mouse   242 GFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGI 306

  Fly   318 RVNRDFVE--RLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLS 380
            .......:  .||         :..|:....:.|.||.|..|:|..|::..::|...:..|.|||
Mouse   307 VAPSTIFDPSELQ---------DLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLS 362

  Fly   381 YYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD----I 441
            ...|.|.||...|.||..|||:|.|:|.|..|.|..||:.:..::.:||...:...|.|.    :
Mouse   363 LDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYL 427

  Fly   442 TLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLVLPL 506
            :..|..|||.||:|::.::.:..:||||||||.:|:..||..|.:|.|:.|...::|.....||.
Mouse   428 STALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPY 492

  Fly   507 IVMGALLILGGFASLLLPETRNRNLPQTLEE 537
            |:||:|.||....:|..||:....||.|:::
Mouse   493 ILMGSLTILTAILTLFFPESFGVPLPDTIDQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	131/402 (33%)
Slc22a5	NP_035526.1	2A0119	12..520	CDD:273328	169/537 (31%)
Slc22a5	NP_035526.1	MFS	123..510	CDD:119392	126/395 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843891
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.880