DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a3

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_035525.1	Gene:	Slc22a3 / 20519	MGIID:	1333817	Length:	551	Species:	Mus musculus

Alignment Length:	582	Identity:	171/582 - (29%)
Similarity:	290/582 - (49%)	Gaps:	57/582 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHF-CRVP------ELEPWT- 59
            ||:.||:.|.||.:|:.:...:.| ..:..||.....:|:.:.|.:: ||.|      |...|:
Mouse     4 FDQALRKAGEFGRFQRRVFLLLCL-TGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSP 67

  Fly    60 -QDYVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVV 123
             :::......|.:|..|.| ...|..|....|:....|...|           |......:..:|
Mouse    68 EEEWNLTTPELHVPAERRG-QGHCHRYLLEATNTSSELSCDP-----------LTAFPNRSAPLV 120

  Fly   124 PCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAY 188
            .|...|.|.::  .||:|.:::|||..::::.|...:..:|.|.|.:..||..|.:||
Mouse   121 SCSGDWRYVET--HSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGR------- 176

  Fly   189 LLLEIIAC-------AASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVS 246
            |::.:|:|       ...|||.|:..::..||:.|:.......:.:|:..|:||.::|....||.
Mouse   177 LIIYLISCFGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVI 241

  Fly   247 NIAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVM 311
            .:.::||:::|.|:.|....|:.:.||:|:|..:....::|:|||||||:...:..:|::||:.:
Mouse   242 QMFFTLGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRV 306

  Fly   312 ARVNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVY 376
            |:.||..::.::.|       ||...|..|:.:    .|||.|.|.||:.|||:...||.:..||
Mouse   307 AKCNGKHLSSNYSE-------ITVTDEEVSNPS----CLDLVRTPQMRKCTLILMFAWFTSAVVY 360

  Fly   377 VGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD- 440
            .||......:||:...:||::|.||||..||:...:...|||.....|.:|.||:|:.|...|:
Mouse   361 QGLVMRLGLIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEG 425

  Fly   441 ---ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIP-MINHMGQQM 501
               :...:..:|::||:.:|.::.|:.||||||.:|..|:|..|.:...|.|:.| ::..:....
Mouse   426 IPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIW 490

  Fly   502 LVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPNNIRAS 563
            |.||||:.|.|..:.|...:|||||:...||:|:|:.|.:..|.|..|   ..:|...:..|
Mouse   491 LELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQC---GRKKKTQVSTS 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	127/407 (31%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	159/543 (29%)
Slc22a3	NP_035525.1	MFS	145..513	CDD:119392	119/385 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850