DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a2

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus

Alignment Length:	586	Identity:	184/586 - (31%)
Similarity:	291/586 - (49%)	Gaps:	68/586 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEVLREVGSFGLYQKVIICSVLLPAALPCAFHA--YSQLFIAATPQHFCRVPELEPWTQ-----D 61
            |::|..:|.|.|:||.   :..|.|.|..||..  ...:|:..||.|.||.|.:...:|     .
Mouse     5 DDILEHIGEFHLFQKQ---TFFLLALLSGAFTPIYVGIVFLGFTPNHHCRSPGVAELSQRCGWSP 66

  Fly    62 YVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRY--------LEYRPPPDLLRQQAEDLLKLQPD 118
            ..:|  |.::|  ..|:..|.|..|:    .:||        |:...|...|......|
Mouse    67 AEEL--NYTVP--GLGSAGEVSFLSQ----CMRYEVDWNQSTLDCVDPLSSLAANRSHL------ 117

  Fly   119 TTQVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRP 183
              .:.||:|||.||..  .|::|.|:||||..|:::.|...:..||..:|....|||.|.:||:.
Mouse   118 --PLSPCEHGWVYDTP--GSSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKF 178

  Fly   184 SFYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNI 248
            .....:|:..|:....|.:.||...|..||:.||...|.....|:|..|.||...|....|...|
Mouse   179 CLLVTILINAISGVLMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQI 243

  Fly   249 AYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMAR 313
            |:::||::||||.|.:.:||.|..||::|.......|:.:|||||||::..|..:|:||:|.:|:
Mouse   244 AFTVGLLILAGVAYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAK 308

  Fly   314 VNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVG 378
            .||    :.....||     :..|:..:.|..:...|||.|.|.:|:.|||:...||.::.:|.|
Mouse   309 KNG----KSVPVSLQ-----SLTADEDTGMKLNPSFLDLVRTPQIRKHTLILMYNWFTSSVLYQG 364

  Fly   379 LSYYAPALGGDEIW-NFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD-- 440
            |..:. .|.||.|: :||.:..||.|...::...:...|||:...:|.:|.|.||:|:...||
Mouse   365 LIMHM-GLAGDNIYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDL 428

  Fly   441 --ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIP-MINHMGQQML 502
              :.:.:.|:|:|||:.::.::.|:.:|||||.:|.|.:...|.:..:|.||.| ::..:....|
Mouse   429 QWLKITVACLGRMGITIAYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWL 493

  Fly   503 VLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPNNIRASPKKR 567
            ..||:|...:.::.|...||||||:.:.||:|:|:.|.:             ::|   |...:||
Mouse   494 EFPLVVFAVVGLVAGGLVLLLPETKGKALPETIEDAEKM-------------QRP---RKKKEKR 542

  Fly   568 I 568
            |
Mouse   543 I 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	134/401 (33%)
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	174/543 (32%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	127/378 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843837
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850