DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Balat and Slc22a8

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	554	Identity:	184/554 - (33%)
Similarity:	277/554 - (50%)	Gaps:	65/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVP---ELEPWTQDY 62
            |.|.|:|..|||.|.:|.:.:..:.|| .|..|.|...|:|.|.||.|.||.|   .||||.
Mouse     1 MTFSEILDRVGSMGPFQYLHVTLLALP-ILGIANHNLLQIFTATTPDHHCRPPPNASLEPWV--- 61

  Fly    63 VQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQ--VVPC 125
                    :|...||...:|          :|:: :.|...|            |:.||  ..||
Mouse    62 --------LPLGPNGKPEKC----------LRFV-HLPNASL------------PNDTQGATEPC 95

  Fly   126 QHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSF-YAYL 189
            ..||.|:.:  ..|:|.||:|||..:.|..:|..||..|.|:|..|||.|.|.:||:|.. ::||
Mouse    96 LDGWIYNST--RDTIVTEWDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYL 158

  Fly   190 LLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGL 254
            ||.....:| ||:.:...::..||:.|.::..|..|..:|.:|.|....|...:......|::|.
Mouse   159 LLAASGSSA-AFSPSLTVYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQ 222

  Fly   255 VVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRV 319
            .:|.|:.|.|..||.|.|:||....:.....:.:|||.|||:..||..:|:|.|:.:|..||.:.
Mouse   223 FILPGLAYAVPQWRWLQLSVSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKE 287

  Fly   320 NRD--FVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSYY 382
            ..:  .||.|:..|     .:..:|....||:.||||...:||.|..::|.|||     .|.:||
Mouse   288 EGEKLTVEELKFNL-----QKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFA-----TGFAYY 342

  Fly   383 APALGGDEIW-NFFLA----GAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVA-TFLYPDI 441
            :.|:|.:|.. |.::.    |.|::|...:....:||.|||......:::.|||.:| .|:..::
Mouse   343 SLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSISYLGRRITQGFLLILAGVAILALIFVSSEM 407

  Fly   442 TLL---LYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLV 503
            .||   |...||..:|.||..|.|..|||||||:|..||..|::.:.||.::.|::...|:....
Mouse   408 QLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPF 472

  Fly   504 LPLIVMGALLILGGFASLLLPETRNRNLPQTLEE 537
            :|.::.|.:.:|||.|:..|.||.||.||:|:|:
Mouse   473 IPNVIFGTMTLLGGSAAFFLLETLNRPLPETIED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	136/407 (33%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	177/539 (33%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844030
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.980