DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a6

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	592	Identity:	172/592 - (29%)
Similarity:	272/592 - (45%)	Gaps:	80/592 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPE---------LE 56
            |.|:::|::||..|.:|.:.:..|:.|..| .|.|...|.|.||.|.|.||.|.         ||
Mouse     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLL-MASHNTLQNFTAAIPAHHCRPPANANLSKDGGLE 64

  Fly    57 PWTQDYVQLVKNLSIPRNRNGAYAECSM--YSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDT 119
            .|            :|.::.|....|..  :..|.|:                        ...|
Mouse    65 AW------------LPLDKQGRPESCLRFPFPHNGTE------------------------ANGT 93

  Fly   120 TQVVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPS 184
            ....||..||.||.|.:.||:|.||||||.......||..:|.||.|||..:||||.|..|||..
Mouse    94 GVTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKV 158

  Fly   185 FYAYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIA 249
            .....|...::...:|:|.||..:...|.:.|:::.:|..:...|.:|.:....|.:...:....
Mouse   159 LILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIAINCMTLNMEWMPIHTRAYVGTLIGYV 223

  Fly   250 YSLGLVVLAGVIYIVRDWRELSLAVSMPLLM--LFSCFFVLPESPRWLMAVGKTRRAIKILKVMA 312
            ||||..:|||:.|.|..||.|.||||:|..:  ::|.||:  ||.||..:.|:....::.|:.:|
Mouse   224 YSLGQFLLAGIAYAVPHWRHLQLAVSVPFFVAFIYSWFFI--ESARWYSSSGRLDLTLRALQRVA 286

  Fly   313 RVNGVRVN--RDFVERLQRKLVITRAAETKSSMTTHYG---ILDLFRGPNMRRKTLIITLIWFAN 372
            |:||.:..  :..:|.||..|        :..:|.:.|   .::|.|.|.:||..|.::::|||.
Mouse   287 RINGKQEEGAKLSIEVLQTSL--------QKELTLNKGQASAMELLRCPTLRRLFLCLSMLWFAT 343

  Fly   373 TSVYVGLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFL 437
            :..|.||.......|........:.|||:||...:.:..::..|||.....|:|:.|:..:...:
Mouse   344 SFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQLASLLLAGICILVNGI 408

  Fly   438 YPD----ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMG 498
            .|.    |...|..:||..::|||..:.|...|||||::|..|:...|.::.||.||.|:|:...
Mouse   409 IPRGHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISMTA 473

  Fly   499 QQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGEAVPLSFLLCCCVESERKPNNIRAS 563
            :....:||.:.||:.:.....:.|||||..:.||.|:::.::           .|..|....:..
Mouse   474 EFYPSIPLFIFGAVPVAASAVTALLPETLGQPLPDTVQDLKS-----------RSRGKQKQQQLE 527

  Fly   564 PKKRILP 570
            .:|:::|
Mouse   528 QQKQMIP 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	129/406 (32%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	163/544 (30%)
		MFS	129..499	CDD:119392	115/379 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545		4/31 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844067
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.980