DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and SLC22A12

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_006718493.1	Gene:	SLC22A12 / 116085	HGNCID:	17989	Length:	578	Species:	Homo sapiens

Alignment Length:	581	Identity:	172/581 - (29%)
Similarity:	270/581 - (46%)	Gaps:	71/581 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQD---- 61
            |.|.|:|..||..|.:| |:....|:.:.:.....:..:.|.||.|.|.|..|.|:..|..
Human     1 MAFSELLDLVGGLGRFQ-VLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASIL 64

  Fly    62 ---YVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVV 123
               ..:.:..:|||...|....:|..:.            :|...||...|......:.||.
Human    65 GSLSPEALLAISIPPGPNQRPHQCRRFR------------QPQWQLLDPNATATSWSEADTE--- 114

  Fly   124 PCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSF-YA 187
            ||..||.||:||::||:|.:||||||...|..:|..::..|.|:|....|...|.:|||... ::
Human   115 PCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWS 179

  Fly   188 YLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAIL-----------------------ASPY-V 228
            ||.:.::..|| |||..:..:...||::...|..::                       |.|. :
Human   180 YLQMAVMGTAA-AFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGL 243

  Fly   229 LAI-ELVGPERRVFCTIVSNIAYSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESP 292
            ||: |......|.....::::.:|.|..:.|.|.|.||||..|.|.||:|..:.|...:.|.||.
Human   244 LAVMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESA 308

  Fly   293 RWLMAVGKTRRAIKILKVMARVNGVRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPN 357
            |||:..|:....::.|..:|.:||....:|   .|..:::::...|..|.......:..|.|.|.
Human   309 RWLLTTGRLDWGLQELWRVAAINGKGAVQD---TLTPEVLLSAMREELSMGQPPASLGTLLRMPG 370

  Fly   358 MRRKTLIITLIWFANTSVYVGLSYYAPALGGDEIWNFFL----AGAVELPT---YLLLWPGLSYF 415
            :|.:|.|.||.|||....:.||:....|||.    |.||    .|.|::|.   .|||   ||:.
Human   371 LRFRTCISTLCWFAFGFTFFGLALDLQALGS----NIFLLQMFIGVVDIPAKMGALLL---LSHL 428

  Fly   416 GRRWILFISMLVGGVACVATFLYPD----ITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLG 476
            |||..|..|:|:.|:..:|..|.|.    :...|..:|..|:.::|..:.:.:|||:|||:|...
Human   429 GRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTA 493

  Fly   477 MSFSSVISMVGPIVIPMINHMGQQMLVLPLIVMGALLILGGFASLLLPETRNRNLPQTLEE 537
            :....:.:..|.|:.|::..:|.....|||:|.|.:.:|.|.|:||||||::..||.|:::
Human   494 VGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQD 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	133/432 (31%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	166/566 (29%)
SLC22A12	XP_006718493.1	MFS	122..541	CDD:119392	131/429 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.980