DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Balat and Slc22a7

DIOPT Version :9

Sequence 1:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_659105.2	Gene:	Slc22a7 / 108114	MGIID:	1859559	Length:	540	Species:	Mus musculus

Alignment Length:	556	Identity:	165/556 - (29%)
Similarity:	269/556 - (48%)	Gaps:	47/556 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQL 65
            |.|:|:|.:||.||.:|...:..:.||..| ...|....:|:||.|.|.|.:|: .|....:..|
Mouse     1 MGFEELLHKVGGFGPFQLRNLVLLALPRFL-LPMHFLLPIFMAAVPAHHCALPD-APANLSHQDL 63

  Fly    66 VKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQ-------QAEDLLKLQPDTTQVV 123
            .....:||..:|:::.|..::        |.:..|...|..:       :.|.|         .|
Mouse    64 WLKTHLPRETDGSFSSCLRFA--------YPQALPNVTLGTEVYNSGEPEGEPL---------TV 111

  Fly   124 PCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAY 188
            ||..||.||:|.:|||:..||:|||.:..|..:....|.:|.|||..|:|||.|.:|||    ..
Mouse   112 PCSQGWEYDRSEFSSTIATEWDLVCQQRGLNKVTSTCFFIGVLLGAVVYGYLSDRFGRR----RL 172

  Fly   189 LLLEIIACAA----SAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIA 249
            ||:..::..|    ||.:.||..::..|.:.|..:.........|.:|.:..|.|....::|...
Mouse   173 LLVAYVSTLALGLMSAASVNYIMFVTTRMLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTTF 237

  Fly   250 YSLGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARV 314
            ::.|:::|..|.|::|.||.|.||.::|.:......:.:|||.|||:..|:...|.|.|.:.|::
Mouse   238 WTGGVLLLTLVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLSICAKL 302

  Fly   315 NGVRVNRDFV--ERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYV 377
            ||..::.|.:  |.|.:.:.:.|.::..|       .|||||...:|..:|...::||.....|.
Mouse   303 NGRPISEDSLSQEALNKVITMERVSQRPS-------YLDLFRTSQLRHVSLCCMMMWFGVNFSYY 360

  Fly   378 GLSYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRR----WILFISMLVGGVACVATFLY 438
            ||:..|..||........|.||||:|:.:.::..:...|||    .:|..:.|..|::.:.:...
Mouse   361 GLTLDASGLGLTVYQTQLLFGAVEVPSKITVFFLVRLVGRRLTEAGMLLATALTFGISLLVSSDT 425

  Fly   439 PDITLLLYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLV 503
            ......|..:||....::|....|..|||||||:|..||.|:::|..:|..:.|::..:....|:
Mouse   426 KSWITALVVIGKAFSEAAFTTAYLFTSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDGVWLL 490

  Fly   504 LPLIVMGALLILGGFASLLLPETRNRNLPQTLEEGE 539
            ||.:..|.:..|.....||||||:...||:|:::.|
Mouse   491 LPKLAYGGISFLAACTVLLLPETKKAQLPETIQDVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	123/405 (30%)
Slc22a7	NP_659105.2	2A0119	11..521	CDD:273328	158/539 (29%)
Slc22a7	NP_659105.2	MFS	146..511	CDD:119392	109/375 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844017
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.880